Diabetologia
Volume 45, Issue 3, 2002, Pages 337-341

Increased end-stage diabetic nephropathy in Indo-Asian immigrants living in the Netherlands (Article) (Open Access)

Chandie Shaw P.K. , Vandenbroucke J.P. , Tjandra Y.I. , Rosendaal F.R. , Rosman J.B. , Geerlings W. , De Charro F.Th. , Van Es L.A.
  • a Department of Nephrology, Leiden University, Medical Center, Leiden, Netherlands
  • b Department of Clinical Epidemiology, Leiden University, Medical Center, Netherlands
  • c Red Cross Hospital, The Hague, Netherlands
  • d Department of Clinical Epidemiology, Leiden University, Medical Center, Netherlands
  • e Medical Center Haaglanden, The Hague, Netherlands
  • f Hospital Leyenburg, The Hague, Netherlands
  • g Renal Replacement Registry Netherlands (RENINE Foundation), Rotterdam, Netherlands
  • h Department of Nephrology, Leiden University, Medical Center, Leiden, Netherlands

Abstract

Aims/hypothesis. We aimed to investigate the risk of end-stage diabetic nephropathy due to Type II (noninsulin-dependent) diabetes mellitus in Indo-Asian immigrants from Surinam. Methods. A demographically based case-control study was carried out in Surinamese Indo-Asian immigrants and Dutch Caucasian subjects. All patients with end-stage diabetic nephropathy who had started dialysis between 1990 and 1998 were identified through a national registry of all patients entering a renal replacement program in the Netherlands. The general population of native Dutch and Surinamese Indo-Asians were considered the control subjects. Results. Among Indo-Asian immigrants, the age adjusted relative risk of end-stage diabetic nephropathy was 38 (95 % CI 16 to 91) compared with the native Dutch population. The duration of diabetes until the start of dialysis treatment was similar in both ethnic groups, about 17 years. Conclusion/interpretation. The Indo-Asian subjects had a nearly 40-fold increase in the risk for end-stage diabetic nephropathy due to Type II diabetes, compared with the native Dutch population. This was higher than expected on the basis of the eightfold higher prevalence of diabetes in the Indo-Asian population. The similar duration of diabetes until the start of dialysis treatment in both ethnic groups supports the hypothesis of a higher incidence of diabetic nephropathy in the Indo-Asian diabetic population. Early and frequent screening for diabetes and microalbuminuria is recommended in Indo-Asian subjects.

Author Keywords

Asians Type II diabetes mellitus Diabetic nephropathy Indo-Asians End-stage renal failure Dialysis Ethnicity Diabetes mellitus Indian

Index Keywords

Netherlands dialysis immigrant Asian Registries Diabetic Retinopathy India non insulin dependent diabetes mellitus risk Indian Diabetes Mellitus, Type 2 human middle aged controlled study priority journal screening test microalbuminuria disease duration Humans Suriname male diabetic nephropathy Diabetic Nephropathies female risk factor Age of Onset high risk population Incidence Article major clinical study adult Kidney Failure, Chronic European Continental Ancestry Group renal replacement therapy Emigration and Immigration patient selection Case-Control Studies
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036202566&doi=10.1007%2fs00125-001-0758-5&partnerID=40&md5=d1f5d1a17d643ab55d1b996606442ee0
DOI: 10.1007/s00125-001-0758-5
ISSN: 0012186X
Cited by: 57
Original Language: English