Journal of Infection in Developing Countries
Volume 12, Issue 2, 2018, Pages 73-79

Extrapulmonary tuberculosis among immigrants in a low-TB burden and high immigrant receiving city of northern Italy (Article) (Open Access)

Di Nuzzo M. , Trentini A. , Grilli A. , Massoli L. , Biagi E. , Maritati M. , Contini C.*
  • a Department of Medical Sciences, Section of Infectious Diseases and Dermatology, University of Ferrara, Ferrara, Italy
  • b Department of Biomedical and Specialist Surgical Sciences, Section of Biochemistry, Biology and Medical Genetic, University of Ferrara, Ferrara, Italy
  • c Department of Medical Sciences, Section of Infectious Diseases and Dermatology, University of Ferrara, Ferrara, Italy
  • d Department of Medical Sciences, Section of Infectious Diseases and Dermatology, University of Ferrara, Ferrara, Italy
  • e Department of Medical Sciences, Section of Infectious Diseases and Dermatology, University of Ferrara, Ferrara, Italy
  • f Department of Medical Sciences, Section of Infectious Diseases and Dermatology, University of Ferrara, Ferrara, Italy
  • g Department of Medical Sciences, Section of Infectious Diseases and Dermatology, University of Ferrara, Ferrara, Italy

Abstract

Introduction: The constantly increasing immigration flows are influencing tuberculosis (TB) epidemiology in several European countries as well as in Italy. Extrapulmonary tuberculosis (EPTB) incidence rate is not decreasing and, among immigrants, it occurs in a remarkable number of cases. This study aimed to provide further insights regarding EPTB among natives and immigrants in a low TB burden and high immigrant receiving setting. Methodology: A total of 217 TB cases admitted to the University-Hospital of Ferrara from 2009 through 2015 were enrolled in the study. Clinical and demographical data including age, gender, origin, single comorbidities such as HIV status, chronic viral disease, chronic lung disease, diabetes, neoplasm, and multimorbidity were analyzed. Results: Of the 217 cases enrolled, 60.0% were immigrants and 40.0% natives, 68.7% presented pulmonary TB and 31.3% EPTB. By binary logistic regression, we observed that female gender (O.R. (95% C.I.): 1.95 (1.08-3.50), p < 0.05), Asian origin (5.70 (2.00-16.24), p < 0.001) and multimorbidity (6.42 (2.37-17.41), p < 0.001) were significantly associated to the development of EPTB compared to PTB. Nodal TB was the most common site of reactivation (56.5% among immigrants and 27.3% among natives). Conclusions: The data we found could be useful in increasing EPTB medical suspicion and decreasing EPTB diagnostic delay in low TB burden and high immigrant receiving settings. © 2018 Di Nuzzo et al.

Author Keywords

Comorbidity Extrapulmonary tuberculosis Immigrant Gender Ethnicity

Index Keywords

Pakistan Romania central nervous system extrapulmonary tuberculosis immigrant chronic lung disease urogenital tract disease virus infection Asian Africa south of the Sahara Europe neoplasm university hospital human comorbidity diabetes mellitus multiple chronic conditions nonhuman Human immunodeficiency virus virus hepatitis disease surveillance male female prevalence Incidence Article major clinical study adult North Africa Italy ethnicity retrospective study disease burden
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043792637&doi=10.3855%2fjidc.10167&partnerID=40&md5=b21924beff59b076dea13d70398a11b6
DOI: 10.3855/jidc.10167
ISSN: 20366590
Cited by: 1
Original Language: English