PLoS Neglected Tropical Diseases
Volume 9, Issue 4, 2015

Using Hospital Discharge Database to Characterize Chagas Disease Evolution in Spain: There Is a Need for a Systematic Approach towards Disease Detection and Control (Article) (Open Access)

Herrador Z.* , Rivas E. , Gherasim A. , Gomez-Barroso D. , García J. , Benito A. , Aparicio P.
  • a National Centre for Tropical Medicine, Health Institute Carlos III (ISCIII in Spanish), Madrid, Spain, Network Biomedical Research on Tropical Diseases (RICET in Spanish), Madrid, Spain
  • b Department of Preventive Medicine, University Hospital Nuestra Señora de la Candelaria, Tenerife, Spain
  • c National Centre for Tropical Medicine, Health Institute Carlos III (ISCIII in Spanish), Madrid, Spain
  • d Biomedical Research Centre Network for Epidemiology and Public Health (CIBERESP), Health Institute Carlos III (ISCIII in Spanish), Madrid, Spain
  • e Department of Preventive Medicine, University Hospital Nuestra Señora de la Candelaria, Tenerife, Spain
  • f National Centre for Tropical Medicine, Health Institute Carlos III (ISCIII in Spanish), Madrid, Spain, Network Biomedical Research on Tropical Diseases (RICET in Spanish), Madrid, Spain
  • g National Centre for Tropical Medicine, Health Institute Carlos III (ISCIII in Spanish), Madrid, Spain, Network Biomedical Research on Tropical Diseases (RICET in Spanish), Madrid, Spain

Abstract

After the United States, Spain comes second in the list of countries receiving migrants from Latin America, and, therefore, it is the European country with the highest expected number of infected patients of Chagas disease. We have studied the National Health System’s Hospital Discharge Records Database (CMBD) in order to describe the disease evolution from 1997 to 2011 in Spain. We performed a retrospective descriptive study using CMBD information on hospitalizations including Chagas disease. Data was divided in two periods with similar length in time: 1997-2004 and 2005-2011. Hospitalization rates were calculated and clinical characteristics were described. We used multivariable logistic regression to calculate adjusted odds-ratio (aOR) for the association between various conditions and being hospitalized with organ affectation. A total of 1729 hospitalization records were identified. Hospitalization rates for the two periods were 18 and 242.8/100000 population, respectively. The median age was 35 years (range 0-87), 74% were female and the 16-45 age-group was mostly represented (69.8%). Overall, 23.4% hospitalizations included the diagnosis of Chagas disease with organ complications. Being male [aOR: 1.3 (1.00-1.77)], aged 45 and 64 years [aOR: 2.59 (1.42-4.71)], and a median hospitalization cost above 3,065 euro [aOR: 2.03 (3.73-7.86)] were associated with hospitalizations with organ affectation. Since 2005, the number of detected infections increased in Spain. The predominant patients’ profile (asymptomatic women at fertile age) and the conditions associated with organ affectation underlines the need for increased efforts towards the early detection of T cruzi. © 2015 Herrador et al.

Author Keywords

[No Keywords available]

Index Keywords

South and Central America hospitalization Latin America economics hospital discharge health insurance human sex difference middle aged Odds Ratio statistics and numerical data Aged Databases, Factual Logistic Models factual database ethnology disease course Humans Treatment Outcome Adolescent male Spain female Infant risk factor Risk Factors prevalence Article disease control Retrospective Studies major clinical study adult migration hospital readmission age Sex Factors Age Factors statistical model Chagas Disease Transients and Migrants retrospective study disease association hospitalization cost Trypanosoma cruzi Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84929497431&doi=10.1371%2fjournal.pntd.0003710&partnerID=40&md5=dd3d2ff4d62d8ba1e5ca31d05ce3eaa2
DOI: 10.1371/journal.pntd.0003710
ISSN: 19352727
Cited by: 7
Original Language: English