Human Immunology
Volume 65, Issue 12, 2004, Pages 1463-1468

Type 1 diabetes in Jewish Ethiopian immigrants in Israel: HLA class II immunogenetics and contribution of new environment (Article)

Zung A. , Elizur M. , Weintrob N. , Bistritzer T. , Hanukoglu A. , Zadik Z. , Phillip M. , Miller K. , Koren I. , Brautbar C. , Israel S.
  • a Pediatric Endocrinology Unit, Kaplan Medical Center, Rehovot, Israel, Israel, Pediatric Endocrinology Unit, Kaplan Medical Center, Rehovot 76100, Israel, Israel
  • b Pediatric Endocrinology Unit, Kaplan Medical Center, Rehovot, Israel, Israel
  • c Institiute Endocrinol. and Diabet., Natl. Center for Childhood Diabetes, Schneider Children's Med. Ctr. I., Israel
  • d Department of Pediatrics, Assaf Harofeh Medical Center, Zerifin, Israel, Israel
  • e Department of Pediatrics, Wolfson Medical Center, Holon, Israel, Israel
  • f Pediatric Endocrinology Unit, Kaplan Medical Center, Rehovot, Israel, Israel
  • g Institiute Endocrinol. and Diabet., Natl. Center for Childhood Diabetes, Schneider Children's Med. Ctr. I., Israel
  • h Tissue Typing Unit, Hadassah University Hospital, Jerusalem, Israel, Israel
  • i Lin Medical Center, Clalit Health Services, Haifa, Israel, Israel
  • j Tissue Typing Unit, Hadassah University Hospital, Jerusalem, Israel, Israel
  • k Tissue Typing Unit, Hadassah University Hospital, Jerusalem, Israel, Israel

Abstract

The interrelationship between human leukocyte antigen immunogenetics and environmental factors and their contribution to the emergence of type 1 diabetes (T1D) were studied in Jewish immigrants from Ethiopia in Israel. This community displays high incidence of T1D, and is unique both by its ethnic segregation and its rapid exposure to a new environment after the immigration. The study population consisted of 152 Ethiopian Jews living in Israel, 33 with T1D and 119 unrelated controls. Human leukocyte antigen class II susceptible and protective alleles in the Jewish Ethiopian patients were similar to those in patients of other ethnic groups in Israel and in non-Jewish Ethiopian patients, with a few exceptions. Three haplotypes were markedly associated with diabetes in Jewish Ethiopian patients: DRB1*0301 DQA1*05 DQB1*02 (OR 4.4, p < 0.001); DRB1*0404 DQA1 03 DQB1*0302 (OR 19.2, p = 0.006), and DRB1*0405 DQA1*03 DQB1*0302 (OR 87.8, p < 0.001). The highly susceptible allele DRB1*0301 was more common in the general Ethiopian population (25.2%) than in all other ethnic groups in Israel, which may render this community prone to the disease. The age at onset of disease in patients with two susceptible haplotypes was negatively correlated with the duration of living in Israel (r = -0.621, p = 0.04). We concluded that ongoing exposure of genetically predisposed immigrants from Ethiopia to diabetogenic environmental factors eventually leads to a high incidence of overt diabetes in this ethnic group. © American Society for Histocompatibility and Immunogenetics, 2004. Published by Elsevier Inc.

Author Keywords

immigrants Type 1 diabetes HLA class II Ethiopia Environment

Index Keywords

genotype immigrant Israel insulin dependent diabetes mellitus correlation analysis human ethnic group controlled study priority journal Environment haplotype Diabetes Mellitus, Type 1 Humans Adolescent male environmental factor female Infant Jew Age of Onset Child, Preschool genetic predisposition Jews clinical article Genes, MHC Class II Incidence immunogenetics Article Gene Frequency Ethiopia Alleles HLA-D Antigens HLA antigen class 2 adult Haplotypes disease predisposition allele Emigration and Immigration Case-Control Studies onset age HLA-DR Antigens Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-10444271712&doi=10.1016%2fj.humimm.2004.09.006&partnerID=40&md5=2838f07c270f15fb005d25c729b8bb30
DOI: 10.1016/j.humimm.2004.09.006
ISSN: 01988859
Cited by: 25
Original Language: English