Han Chinese of low-altitude descent have been living in Qinghai Province of Western China or at least two millennia. For most of this time they have lived at elevations under 2,500 m. However, during the last four decades an increasing number of Han have moved into high-altitude towns at elevations over 3,000 m, and some above 4,000 m. There are now sufficient numbers of Han descendants who have been born and raised at high altitude to allow a comparison of their morphological and physiological growth patterns with low-altitude Han to detect the effect of hypoxia. The field study reported here was conducted by collaborating Chinese and American researchers over a 6-year period, and included 1,227 Han living at high altitude in Qinghai and at low altitude near Beijing. This study demonstrates that Han born and raised at high altitude are smaller and lighter than those at low altitude - particularly as children and adolescents. Slower growth at high altitude may be a consequence of hypoxia, but it also corresponds to poorer economic conditions in rural Qinghai Province, and thus may reflect nutritional inadequacies. Differences in altitude and/or nutrition do not seem to affect thorax dimensions, since, relative to stature, chest dimensions are similar at both high and low altitudes. Nevertheless, lung volumes are higher among Han at high altitude, possibly reflecting the influence of hypoxia on alveolar growth. The hematological values of Han growing up at 3,200 m are not different from those at low altitude - an unusual finding relative to other low-altitude groups that may reflect population differences in response to hypoxia. A 3,800 m and 4,300 m, however, Han show elevated hemoglobi relative to Han at low altitude. © 2004 Wiley-Liss, Inc.

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Altitude China Chinese human altitude disease Asian continental ancestry group ethnic group priority journal population structure population growth hemoglobin determination child growth Humans anatomical variation Anthropology, Physical Adolescent Respiratory Function Tests male lung volume body build female altitude acclimatization growth lung alveolus hematological parameters morphological trait socioeconomics population research Hematologic Tests Article adult hemoglobin anthropometry Transients and Migrants nutritional status thorax population migration Child