Chinese Journal of Clinical Rehabilitation
Volume 8, Issue 16, 2004, Pages 3030-3031

Opposite test on the action duration of acetazolamide to the memory and limb motor abilities of highland immigrants (Article)

Ma Y.* , Ha Z.-D. , Xing G.-X. , Cui J.-H. , Wang W. , Zhang F. , Zhang X.-Z.
  • a Institute of Altitude Disease, 18 Hospital of Chinese PLA, Yechen 844900 Sinkiang, China
  • b Institute of Altitude Disease, 18 Hospital of Chinese PLA, Yechen 844900 Sinkiang, China
  • c Institute of Altitude Disease, 18 Hospital of Chinese PLA, Yechen 844900 Sinkiang, China
  • d Institute of Altitude Disease, 18 Hospital of Chinese PLA, Yechen 844900 Sinkiang, China
  • e Institute of Altitude Disease, 18 Hospital of Chinese PLA, Yechen 844900 Sinkiang, China
  • f Institute of Altitude Disease, 18 Hospital of Chinese PLA, Yechen 844900 Sinkiang, China
  • g Institute of Altitude Disease, 18 Hospital of Chinese PLA, Yechen 844900 Sinkiang, China

Abstract

Aim: To investigate the effect of acetazolamide in improving and prolonging memory and limb motor abilities of highland immigrants. Methods: A trial was performed on 40 healthy young men, Han Nationality, having lived for 6 months at 3 700-meter altitude, who were randomly divided into acetazolamide group (group A, n = 20) and placebo group (group B, n = 20). Hand-feet-cross frequency and memory of past numbers were tested pre- and post-exercises before taking medicine, taking for 10 day, (withdrawal) and 10 days after withdrawal by DDX-200 multifunction psychological machine. Load exercise tests were carried out by the EGM bicycle ergometer specific simultaneously. Results: In the hand-feet-cross test, group A had more total times and right times pre- and post-exercise after taking medicine for 10 days and 10 days after withdrawal(P < 0.01 or < 0.05) and had much less wrong times(P < 0.01). Group A had more total times and right times 10 days after withdrawal in comparison with those pre- or post-exercises before taking medicine (P < 0.01 or P < 0.05) and had much less wrong times(P < 0.01). The score of memory-span in past numbers test of group A was increased significantly pre- and post-exercises after taking medicine for 10 days (6.1 ± 1.3 and 5.7 ± 1.4) and 10 days after withdrawal (5.2 ± 1.3 and 4.9 ± 1.0) as compared with those in group B (3.3 ± 0.9, 3.1 ± 1.2, 3.2 ± 1.4 and 3.1 ± 1.1 respectively) (t = 4.76 - 8.23, P < 0.01); the scores in group A was increased significantly as compared with those before taking medicine(P < 0.01 or P < 0.05). Conclusion: Acetazolamide can improve memory and limb motor abilities of highland immigrants effectively, and the physiological effect can last 10 days after withdrawal.

Author Keywords

[No Keywords available]

Index Keywords

motor performance Altitude immigrant controlled clinical trial memory clinical trial human exercise test controlled study drug efficacy male placebo scoring system psychologic test Article drug mechanism bicycle ergometry acetazolamide loading test drug withdrawal drug activity frequency analysis human experiment
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-3543113783&partnerID=40&md5=03ff8eab31661af08eca0c09224ae967
ISSN: 16715926
Original Language: Chinese