Annals of Tropical Medicine and Parasitology
Volume 97, Issue 6, 2003, Pages 557-564

Onset of clinical immunity to Plasmodium falciparum among Javanese migrants to Indonesian Papua (Article)

Baird J.K.* , Krisin , Barcus M.J. , Elyazar I.R.F. , Bangs M.J. , Maguire J.D. , Fryauff D.J. , Richie T.L. , Sekartuti , Kalalo W.
  • a U. States Naval Med. Res. Unit #2, American Embassy Jakarta, FPO, AP 96520-8132, United States, U.S. Naval Med. Res. Ctr. Detachment, American Embassy Lima, APO, AA 34031-3800, United States
  • b U. States Naval Med. Res. Unit #2, American Embassy Jakarta, FPO, AP 96520-8132, United States
  • c U. States Naval Med. Res. Unit #2, American Embassy Jakarta, FPO, AP 96520-8132, United States
  • d U. States Naval Med. Res. Unit #2, American Embassy Jakarta, FPO, AP 96520-8132, United States
  • e U. States Naval Med. Res. Unit #2, American Embassy Jakarta, FPO, AP 96520-8132, United States
  • f U. States Naval Med. Res. Unit #2, American Embassy Jakarta, FPO, AP 96520-8132, United States
  • g U. States Naval Med. Res. Unit #2, American Embassy Jakarta, FPO, AP 96520-8132, United States, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, United States
  • h U. States Naval Med. Res. Unit #2, American Embassy Jakarta, FPO, AP 96520-8132, United States, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, United States
  • i National Center for Health Research, Jalan Percetakan Negara No. 29, Jakarta 10560, Indonesia
  • j Papua Provincial Health Services, Jayapura, Papua, Indonesia

Abstract

Onset of clinical immunity to Plasmodium falciparum occurred among Javanese migrants to Indonesian Papua. Surveillance of the 243 migrants investigated began on the day of their arrival in Indonesian Papua and continued for 33 months. Asexual parasitaemia without fever constituted objective evidence of clinical immunity. Compared with first infection, the odds ratio (OR) for not having fever at the fourth infection within 24 months was 3.2 [95% confidence interval (CI) = 1.03-10.2; P = 0.02]. The corresponding OR with fewer infections within 24 months was not distinguishable from 1.0. The level of the fourth parasitaemia within 24 months (N = 58) was classified as 'high' or 'low' in relation to the median count at first infection (840 parasites/μl; N = 187). Fourth parasitaemias that were low - but not those that were high (OR = 1.8; CI = 0.6-5.4; P = 0.35) - were associated with dramatic protection from fever (OR = 31; CI = 3.5-1348; P = 0.0001). Among the adult subjects, the risk of fever with low parasitaemia was significantly higher at the first infection than at the fourth (OR = 12.6; CI = 1.7-530; P = 0.005), indicating the development of clinical immunity. A similar but less marked pattern appeared among the children investigated (OR = 6.5; CI = 0. 8-285; P = 0.06).

Author Keywords

[No Keywords available]

Index Keywords

disease classification immigrant risk Follow-Up Studies follow up human Odds Ratio controlled study Malaria Time Factors Humans Adolescent male Chi-Square Distribution Staphylococcus phage 187 female parasite immunity risk factor Indonesia high risk population Protozoa Recurrence Article Papua New Guinea Parasitemia major clinical study adult fever Malaria, Falciparum Age Factors Plasmodium falciparum Transients and Migrants Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0041639579&doi=10.1179%2f000349803225001472&partnerID=40&md5=4d546a4722f4eaad219566aae69b9cc3
DOI: 10.1179/000349803225001472
ISSN: 00034983
Cited by: 29
Original Language: English