Annals of Tropical Medicine and Parasitology
Volume 97, Issue 6, 2003, Pages 543-556

Malaria in a cohort of Javanese migrants to Indonesian Papua (Article)

Krisin , Basri H. , Fryauff D.J. , Barcus M.J. , Bangs M.J. , Ayomi E. , Marwoto H. , Elyazar I.R.F. , Richie T.L. , Baird J.K.*
  • a U. States Naval Med. Res. Unit #2, American Embassy Jakarta, FPO, AP 96520-8132, United States
  • b U. States Naval Med. Res. Unit #2, American Embassy Jakarta, FPO, AP 96520-8132, United States
  • c U. States Naval Med. Res. Unit #2, American Embassy Jakarta, FPO, AP 96520-8132, United States, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, United States
  • d U. States Naval Med. Res. Unit #2, American Embassy Jakarta, FPO, AP 96520-8132, United States
  • e U. States Naval Med. Res. Unit #2, American Embassy Jakarta, FPO, AP 96520-8132, United States
  • f Papua Provincial Health Service, Jayapura, Papua, Indonesia
  • g Indonesian Ministry of Health, Inst. of Hlth. R and D, Departemen Kesehatan, Jalan Percetakan Negara No. 29, Jakarta 10560, Indonesia
  • h U. States Naval Med. Res. Unit #2, American Embassy Jakarta, FPO, AP 96520-8132, United States
  • i U. States Naval Med. Res. Unit #2, American Embassy Jakarta, FPO, AP 96520-8132, United States, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, United States
  • j U. States Naval Med. Res. Unit #2, American Embassy Jakarta, FPO, AP 96520-8132, United States, U.S. Naval Med. Res. Ctr. Detachment, American Embassy Lima, APO, AA 34031-3800, United States

Abstract

The epidemiology of infection by Plasmodium falciparum and P. vivax was investigated among Javanese migrants to an endemic region of Papua, Indonesia. A cohort of 243 migrants from Java was followed for malaria in a new settlement village in the endemic Armopa area of north-eastern Papua, beginning on the day each migrant arrived in the village. The subjects were monitored during home visits (three/week) and by the twice-monthly production of bloodsmears that were checked for malarial parasites. At the end of 33 months, 159 (65%) of the subjects remained under follow-up. The prevalence of parasitaemia in the village declined from 16% among those already living there when the study began in August 1996, to 5% when the study finished in June 1999. Over this period, 596 infections by P. falciparum and 723 by P. vivax occurred in the cohort, 22 and 27 of the subjects each experiencing at least six infections by P. falciparum and P. vivax, respectively. The incidence of malarial infection was higher during the first and second years post-migration (3.2 and 2.7 infections/person-year) than during the third (1.2 infections/person-year). Although the geometric mean parasite counts for P. falciparum increased over time (1209, 1478, and 1830 parasites/μl in the first, second and third years, respectively), the corresponding values for P. vivax (497, 535 and 490 parasites/μl) showed no such trend. Only one of the nine subjects who developed severe malaria (requiring intravenous quinine therapy) was a child, giving an odds ratio for a case of severe malaria being in an adult of 6.1 (P = 0.08).

Author Keywords

[No Keywords available]

Index Keywords

immigrant Follow-Up Studies follow up human controlled study Malaria Cross-Sectional Studies Treatment Failure Humans Adolescent Treatment Outcome Antimalarials male female Cinchona pubescens Indonesia prevalence Incidence Protozoa Article Papua New Guinea Parasitemia Plasmodium vivax Malaria, Vivax primaquine adult major clinical study Malaria, Falciparum endemic disease Plasmodium falciparum disease severity Transients and Migrants fansidar quinine mefloquine chloroquine Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0042140588&doi=10.1179%2f000349803225001454&partnerID=40&md5=da9c5ec4d8f3176cf3a6d347ba8a7819
DOI: 10.1179/000349803225001454
ISSN: 00034983
Cited by: 15
Original Language: English