Journal of the National Cancer Institute
Volume 95, Issue 16, 2003, Pages 1238-1240

Age at immigration and duration of stay in relation to risk for testicular cancer among Finnish immigrants in Sweden (Article) (Open Access)

Ekbom A.* , Richiardi L. , Akre O. , Montgomery S.M. , Sparén P.
  • a Clinical Epidemiology Unit, Department of Medicine, Karolinska Hospital, SE-171 76 Stockholm, Sweden, Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States
  • b Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
  • c Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
  • d Clinical Epidemiology Unit, Department of Medicine, Karolinska Hospital, SE-171 76 Stockholm, Sweden
  • e Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden

Abstract

Although the incidence of testicular cancer is increasing, substantial differences in incidence between countries and populations exist. These differences cannot be explained solely by genetic differences, but environmental exposures, particularly early exposures, have been implicated in the etiology of testicular cancer. To assess whether early exposures contribute to the incidence of testicular cancer, we identified 93 172 Finnish men who immigrated to Sweden between 1969 and 1996 and followed them for the occurrence of testicular cancer. The risk of testicular cancer was lower for Finnish immigrants to Sweden than for the Swedish general population (standardized incidence ratio [SIR] = 0.34, 95% confidence interval [CI] = 0.21 to 0.53). The reduced risk was associated with both seminomas and non-seminomas. Neither age at immigration nor duration of stay in Sweden had any impact on the reduced risk. Although the type of environmental exposures remains unknown, the results strongly indicate that early exposures are major determinants for testicular cancer.

Author Keywords

[No Keywords available]

Index Keywords

Finland follow up human risk assessment immigration middle aged Cohort Studies controlled study priority journal cancer risk Time Factors Aged ethnology Confidence interval epidemiological data Sweden Humans Adolescent male testis cancer Testicular Neoplasms Infant risk factor Risk Factors environmental exposure testis tumor high risk population population research Incidence Article Dysgerminoma major clinical study adult migration age Age Factors seminoma age distribution cohort analysis Emigration and Immigration disease association cancer incidence time Child

Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0042913352&doi=10.1093%2fjnci%2fdjg012&partnerID=40&md5=b4f49cec628b16a6040ac2dc16b9e788

DOI: 10.1093/jnci/djg012
ISSN: 00278874
Cited by: 44
Original Language: English