World Allergy Organization Journal
Volume 12, Issue 12, 2019
The protective effect of rural life on mite sensitization disappears among urban migrants in the South of Vietnam (Article) (Open Access)
Chu H.T. ,
Tran T.N. ,
Doyen V. ,
Denis O. ,
Tran T.T.T. ,
Nguyen T.K.D. ,
Nguyen H.L. ,
Ngo M.X. ,
Tran T.M.H. ,
Corazza F. ,
Bouland C. ,
Hauglustaine J.-M. ,
Godin I. ,
Michel O.*
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a
Pham Ngoc Thach Hospital, Ho Chi Minh City, Viet Nam, Clinic of Immuno-allergology, CHU Brugmann, Université Libre de Bruxelles (ULB), 4 Place A Van Gehuchten, Brussels, B -1020, Belgium
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b
Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam, School of Public Health, ULB, Brussels, Belgium
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c
Clinic of Immuno-allergology, CHU Brugmann, Université Libre de Bruxelles (ULB), 4 Place A Van Gehuchten, Brussels, B -1020, Belgium
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d
Service Immune Response, Sciensano, Brussels, Belgium
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e
Industrial University of Ho Chi Minh City, Ho Chi Minh City, Viet Nam
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f
Industrial University of Ho Chi Minh City, Ho Chi Minh City, Viet Nam
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g
Pham Ngoc Thach Hospital, Ho Chi Minh City, Viet Nam
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h
Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam
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i
Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam
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j
Laboratory of Immunology, CHU Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium
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k
School of Public Health, ULB, Brussels, Belgium
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l
Energy Sud, Faculty of Sciences, Université de Liège (ULiège), Liège, Belgium
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m
School of Public Health, ULB, Brussels, Belgium
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n
Clinic of Immuno-allergology, CHU Brugmann, Université Libre de Bruxelles (ULB), 4 Place A Van Gehuchten, Brussels, B -1020, Belgium
Abstract
Background: Rapid urbanization combined with rural migration to urban areas in southern Vietnam could be risk factors for allergen sensitization, contributing to chronic respiratory diseases (CRD). We aimed to evaluate the prevalence of mite sensitization and its relation to house dust characteristics among rural and urban native and migrating populations with CRD. Methods: Rural (n = 19) and urban (n = 46) dwellings were defined on the basis of a home typology. Controls were western Belgian houses (n = 14). Besides the house characteristics, both endotoxin and mite allergens were measured in the settled dusts. The sensitization to mite allergens was defined by positive skin prick test (SPT) and concentration of specific IgE (sIgE)≥ 0.7 U/mL. The prevalence of mite sensitization was evaluated among 610 patients with CRD and compared according to both their home types and places of birth and residences. Results: The concentration of endotoxin (but not mite allergen) was higher in rural compared to urban dusts (440 (95%CI: 314–566) versus 170 (95%CI: 115–226) EU/mg; p < 0.0001). The prevalence of positive sIgE to Der p1 and Der p2 was significantly lower in rural (9% and 5%) compared to urban (15% and 9%) population, consistent with the positive SPT to mite (14% and 21%, respectively). Among the urban migrants, the risk of mite sensitization (SPT) was higher compared to the rural natives (OR: 1.79 (1.02–3.15), p < 0.05) and not different to the urban ones (OR: 1.35 (0.82–2.23) p NS). Conclusion: In Vietnam, associated with higher endotoxin (but not allergen) dust concentrations, the risk of mite sensitization was lower in rural compared to the native urban population, but this protective effect could disappear among rural to urban migrants. © 2019 The Author(s)
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Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075495230&doi=10.1016%2fj.waojou.2019.100085&partnerID=40&md5=98429ed40bbad3c18bf902ddc7748472
DOI: 10.1016/j.waojou.2019.100085
ISSN: 19394551
Original Language: English