Public Health Nursing
Volume 36, Issue 3, 2019, Pages 257-269

Risk factors of multidrug-resistant tuberculosis in China: A meta-analysis (Article)

Feng M. , Xu Y. , Zhang X. , Qiu Q. , Lei S. , Li J. , Yuan W. , Song Q. , Xu J.*
  • a Department of Hyperbaric Oxygen, Guizhou Provincial People's Hospital, Guiyang, Guizhou Province, China
  • b Department of Urology, People's Hospital Affiliated to Guizhou Medical University, Guiyang, China
  • c Department of Respiratory and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, Guizhou Province, China
  • d Department of Internal Medicine, Chongqing Public Health Center, Chongqing, China
  • e Guizhou Provincial Center for Disease Control and Prevention, Guiyang, Guizhou, China
  • f Guizhou Provincial Center for Disease Control and Prevention, Institute for Tuberculosis Control and Prevention, Guiyang, Guizhou Province, China
  • g Guizhou Provincial Center for Disease Control and Prevention, Institute for Tuberculosis Control and Prevention, Guiyang, Guizhou Province, China
  • h Guizhou Provincial Center for Disease Control and Prevention, Institute for Tuberculosis Control and Prevention, Guiyang, Guizhou Province, China
  • i Guizhou Provincial Center for Disease Control and Prevention, Institute for Tuberculosis Control and Prevention, Guiyang, Guizhou Province, China

Abstract

Background: Multidrug-resistant tuberculosis (MDR-TB) brings major challenges to the health care workers (HCWs). This study is to determine the risk factors for MDR-TB, latent tuberculosis infection (LTBI), and tuberculosis (TB) disease among HCWs in China. Methods: A meta-analysis was conducted to evaluate the risk factors for MDR-TB, LTBI, and TB disease among HCWs using a random-effects model, and the pooled odds ratios (ORs) with 95% confidence interval (CI) were used as effect indicators. Results: We identified 46 eligible studies and found eight factors were associated with MDR. The ORs with 95% CI are migrant population 1.96 (95% CI, 1.50–2.57), low family income 2.23 (95% CI, 1.74–2.85), retreatment 7.22 (95% CI, 5.63–9.26), anti-TB treatment history 5.65 (95% CI, 4.80–6.65), multiple episodes of treatment 3.28 (95% CI, 2.60–4.13), adverse reactions 3.48 (95% CI, 2.54–4.76), interrupted treatment 3.18 (95% CI, 2.60–3.89), and lung cavities 1.42 (95% CI, 1.14–1.77). Work duration as a HCW for 5 years and above increased the risk of LTBI and TB. HCWs aged 30 years and above were more susceptible to TB (OR = 1.70, 95% CI: 1.37–2.09). Conclusion: The risk factors for MDR-TB in China are possibly migrant population, low family income, retreatment, anti-TB treatment history, adverse reactions, interrupted treatment, and lung cavities. Longer work duration and greater age are risk factors for LTBI and TB among HCWs. © 2019 Wiley Periodicals, Inc.

Author Keywords

China Health care workers risk factors Meta-analysis Multidrug-resistant tuberculosis

Index Keywords

statistics and numerical data Health Personnel multidrug resistant tuberculosis China latent tuberculosis tuberculosis risk factor Risk Factors Tuberculosis, Multidrug-Resistant health care personnel meta analysis human Humans
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060641156&doi=10.1111%2fphn.12582&partnerID=40&md5=244e6aa886b65b82260cbc91118fbe37
DOI: 10.1111/phn.12582
ISSN: 07371209
Original Language: English