Clinicoepidemiological characteristics of viral hepatitis in migrants and travellers of the +Redivi network

Travel Medicine and Infectious Disease
Volume 29, 2019, Pages 51-57

Clinicoepidemiological characteristics of viral hepatitis in migrants and travellers of the +Redivi network (Article)

Henriquez-Camacho C. , Serre N. , Norman F. , Sánchez-Montalvá A. , Torrús D. , Goikoetxea A.J. , Herrero-Martínez J.M. , Ruiz-Giardín J.M. , Treviño B. , Monge-Maillo B. , Molina I. , Rodríguez A. , García M. , López-Vélez R. , Pérez-Molina J.A.* , Aguilera P. , Serrano M.M. , Rodriguez M.G. , Menendez M.D. , Meije Y. , Martínez-Montauti J. , Sanz X. , Tenza I.P. , Cuello I.G. , López B.M. , LLenas J. , Masiá M. , Padilla S. , Romero M. , Wilkman-Jorgensen P. , Ramos Rincón J.M. , Malmierca E. , Perez-Ayala A. , Herrero J.M. , Lizasoain M. , Rojo P. , Matarranz M. , Zarco C. , Rodriguez-Guardado A. , Suárez J.F. , Boga Ribeiro J.A. , Aguirre J.G. , Zubero Sulibarría M.Z. , Ruiz Giardin J.M. , Sanmartín López J.V. , Arribas M.V. , Muñoz E.C. , Ribas A.M. , Vera M.P. , Montalvá A.S. , Salvador F. , Dominguez Á. , Treviño-Maruri B. , Delcor N.S. , Soriano-Arandes A. , Ciruelo D.P. , Bocanegra C. , Redivi Study Group

^a National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, IRYCIS, Carretera de Colmenar Km 9, 1, Madrid, 28034, Spain
^b Unitat Medicina Tropical I Salut Internacional Vall d´Hebron-Drassanes, PROSICS, Av de Drassanes 17-21, Barcelona, 08001, Spain
^c National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, IRYCIS, Carretera de Colmenar Km 9, 1, Madrid, 28034, Spain, Servicio de Enfermedades Infecciosas, Hospital Ramón y Cajal, Comunidad de Madrid, Spain
^d Department of Infectious Diseases, Vall d´Hebron University Hospital, Universitat Autonoma de Barcelona, PROSICS Barcelona, Passeig Vall d´Hebron 119-129, Barcelona, 08035, Spain
^e Alicante University Hospital, Calle Pintor Baeza 11, Alicante, 03010, Spain, Hospital General Universitario de Alicante, Comunidad Valenciana, Spain
^f Hospital Universitario de Cruces, Plaza de las Cruces s/nBizkaia 48903, Spain
^g Hospital Universitario Doce de Octubre, Av. Cordoba, s/n, Madrid, 28041, Spain
^h Hospital Universitario de Fuenlabrada, Camino del Molino, 2, Madrid, 28942, Spain, Hospital Universitario de Fuenlabrada, Comunidad de Madrid, Spain
ⁱ Unitat Medicina Tropical I Salut Internacional Vall d´Hebron-Drassanes, PROSICS, Av de Drassanes 17-21, Barcelona, 08001, Spain
^j National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, IRYCIS, Carretera de Colmenar Km 9, 1, Madrid, 28034, Spain
^k Department of Infectious Diseases, Vall d´Hebron University Hospital, Universitat Autonoma de Barcelona, PROSICS Barcelona, Passeig Vall d´Hebron 119-129, Barcelona, 08035, Spain, Hospital Universitario Vall d'Hebron, Cataluña, Spain
^l Hospital Universitario Central de Asturias, Av. Roma, s/n, Oviedo Principado de Asturias, 33011, Spain
^m Consorcio Hospital General Universitario de Valencia, Avenida Tres Cruces, 2, Valencia, 46014, Spain
ⁿ National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, IRYCIS, Carretera de Colmenar Km 9, 1, Madrid, 28034, Spain
^o National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, IRYCIS, Carretera de Colmenar Km 9, 1, Madrid, 28034, Spain
^p Centro de Atención Primaria Guayaba, Comunidad de Madrid, Spain
^q Complejo Hospitalario Universitario de Albacete, Comunidad de Castilla-La Mancha, Spain
^r Consorcio Hospital General Universitario de Valencia, Comunidad Valenciana, Spain
^s Hospital Carlos III-La Paz, Comunidad de Madrid, Spain
^t Hospital de Barcelona, Cataluña, Spain
^u Hospital de Barcelona, Cataluña, Spain
^v Hospital de Barcelona, Cataluña, Spain
^w Hospital de la Vega Baja de Orihuela, Comunidad Valenciana, Spain
^x Hospital de la Vega Baja de Orihuela, Comunidad Valenciana, Spain
^y Hospital de la Vega Baja de Orihuela, Comunidad Valenciana, Spain
^z Hospital de la Vega Baja de Orihuela, Comunidad Valenciana, Spain
^a Hospital General de Elche, Comunidad Valenciana, Spain
^b Hospital General de Elche, Comunidad Valenciana, Spain
^c Hospital General de Elda-Virgen de la Salud, Comunidad Valenciana, Spain
^d Hospital General de Elda-Virgen de la Salud, Comunidad Valenciana, Spain
^e Hospital General Universitario de Alicante, Comunidad Valenciana, Spain
^f Hospital Infanta Sofía, Comunidad de Madrid, Spain
^g Hospital Universitario 12 de Octubre, Madrid Comunidad de Madrid, Spain
^h Hospital Universitario 12 de Octubre, Madrid Comunidad de Madrid, Spain
ⁱ Hospital Universitario 12 de Octubre, Madrid Comunidad de Madrid, Spain
^j Hospital Universitario 12 de Octubre, Madrid Comunidad de Madrid, Spain
^k Hospital Universitario 12 de Octubre, Madrid Comunidad de Madrid, Spain
^l Hospital Universitario 12 de Octubre, Madrid Comunidad de Madrid, Spain
^m Hospital Universitario Central de Asturias, Oviedo Principado de Asturias, Spain
ⁿ Hospital Universitario Central de Asturias, Oviedo Principado de Asturias, Spain
^o Hospital Universitario Central de Asturias, Oviedo Principado de Asturias, Spain
^p Hospital Universitario Cruces de Barakaldo, España País Vasco, Bilbao, Spain
^q Hospital Universitario de Basurto de Bilbao, País Vasco, Spain
^r Hospital Universitario de Fuenlabrada, Camino del Molino, 2, Madrid, 28942, Spain, Hospital Universitario de Fuenlabrada, Comunidad de Madrid, Spain
^s Hospital Universitario de Fuenlabrada, Comunidad de Madrid, Spain
^t Hospital Universitario Fundación de Alcorcón, Comunidad de Madrid, Spain
^u Hospital Universitario La Fe de Valencia, Comunidad Valenciana, Spain
^v Hospital Universitario Son EspasesIslas Baleares, Spain
^w Hospital Universitario Son EspasesIslas Baleares, Spain
^x Hospital Universitario Vall d'Hebron, Cataluña, Spain
^y Hospital Universitario Vall d'Hebron, Cataluña, Spain
^z Hospital Universitario Virgen de la Macarena de Sevilla, Andalucía, Spain
^a Unitat de Salut Internacional Drassanes, PROSICS, Cataluña, Spain
^b Unitat de Salut Internacional Drassanes, PROSICS, Cataluña, Spain
^c Unitat de Salut Internacional Drassanes, PROSICS, Cataluña, Spain
^d Unitat de Salut Internacional Drassanes, PROSICS, Cataluña, Spain
^e Unitat de Salut Internacional Drassanes, PROSICS, Cataluña, Spain
^f [Affiliation not available]

Abstract

Background: Continuous growth of mobile populations has influenced the global epidemiology of infectious diseases, including chronic and acute viral hepatitis. Method: A prospective observational multicentre study was performed in a Spanish network of imported infections. Viral hepatitis cases from January 2009 to September 2017 were included. Results: Of 14,546 records, 723 (4.97%) had imported viral hepatitis, including 48 (6.64%) acute cases and 675 (93.36%) chronic cases. Of the 48 acute cases, 31 were travellers and immigrants returning from visiting friends or relatives (VFR), while 19 (61%) were acute Hepatitis A or Hepatitis B. Only 18.2% of VFR immigrants and 35% of travellers received pre-travel advice. Acute hepatitis was more frequent in VFR immigrants (AOR 2.59, CI95% 1.20–5.60) and travellers (AOR 2.83, CI95% 1.46–5.50) than immigrants. Of the 675 Chronic cases, 570 were immigrants, and 439 (77%) had chronic Hepatitis B. Chronic hepatitis was more frequent in immigrants (AOR 20.22, CI95% 11.64–35.13) and VFR immigrants (AOR 11.12, CI95% 6.20–19.94) than travellers. Conclusions: Chronic viral hepatitis was typical of immigrants, acute viral hepatitis was common among travellers, and VFR immigrants had mixed risk. Improving pre-travel consultation and screening of immigrants may contribute to preventing new cases of viral hepatitis and avoiding community transmission. © 2019 Elsevier Ltd

Author Keywords

Travellers immigrants Viral hepatitis

Index Keywords

prospective study immigrant Immunosuppression acute hepatitis C acute hepatitis B acute hepatitis A multicenter study primary medical care clinical trial clinical feature Prospective Studies human middle aged travel related disease travel statistics and numerical data controlled study priority journal screening test virus hepatitis Young Adult immunosuppressive treatment migrant Humans Adolescent consultation male Spain female risk factor Risk Factors acute hepatitis observational study chronic hepatitis Communicable Diseases, Imported Article communicable disease adult major clinical study migration Hepatitis, Viral, Human chronic hepatitis B virus transmission Transients and Migrants emporiatrics mixed infection

Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061155988&doi=10.1016%2fj.tmaid.2019.02.001&partnerID=40&md5=530ae90f56a90b485f27fedac5ed6ef8

DOI: 10.1016/j.tmaid.2019.02.001

ISSN: 14778939

Original Language: English