Antimicrobial Agents and Chemotherapy
Volume 63, Issue 5, 2019

Mutation Profile of pfdhfr and pfdhps in Plasmodium falciparum among Returned Chinese Migrant Workers from Africa (Article) (Open Access)

Xu C. , Sun H. , Wei Q. , Li J. , Xiao T. , Kong X. , Wang Y. , Zhao G. , Wang L. , Liu G. , Yan G. , Huang B.* , Yin K.
  • a Shandong Institute of Parasitic Diseases, Shandong Academy of Medical Sciences, Jining, China
  • b Shandong Institute of Parasitic Diseases, Shandong Academy of Medical Sciences, Jining, China
  • c Shandong Institute of Parasitic Diseases, Shandong Academy of Medical Sciences, Jining, China
  • d Shandong Institute of Parasitic Diseases, Shandong Academy of Medical Sciences, Jining, China
  • e Shandong Institute of Parasitic Diseases, Shandong Academy of Medical Sciences, Jining, China
  • f Shandong Institute of Parasitic Diseases, Shandong Academy of Medical Sciences, Jining, China
  • g Shandong Institute of Parasitic Diseases, Shandong Academy of Medical Sciences, Jining, China
  • h Shandong Institute of Parasitic Diseases, Shandong Academy of Medical Sciences, Jining, China
  • i Shandong Institute of Parasitic Diseases, Shandong Academy of Medical Sciences, Jining, China
  • j Shandong Institute of Parasitic Diseases, Shandong Academy of Medical Sciences, Jining, China
  • k Shandong Institute of Parasitic Diseases, Shandong Academy of Medical Sciences, Jining, China
  • l Shandong Institute of Parasitic Diseases, Shandong Academy of Medical Sciences, Jining, China
  • m Shandong Institute of Parasitic Diseases, Shandong Academy of Medical Sciences, Jining, China

Abstract

We evaluated markers of sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum among 254 returned migrant workers in China from Africa from 2013 to 2016. High prevalences of pfdhfr (97.2%) and pfdhps (96.5%) mutations were observed. The partially resistant genotype was homogeneously distributed in Africa with a modestly high prevalence (48%), whereas the super resistant genotype was only found in West Africa with a very low frequency (1.2%). The findings provided baseline data about the molecular markers of SP resistance. Copyright © 2019 American Society for Microbiology. All Rights Reserved.

Author Keywords

China Pfdhps SP resistance Pfdhfr Malaria Genotype Plasmodium falciparum Africa Mutation

Index Keywords

genotype point mutation health care policy human priority journal geographic distribution mutation rate pfdhfr gene pfdhps gene pyrimethamine plus sulfadoxine dihydropteroate synthase dihydrofolate reductase nucleotide sequence migrant worker male female Equatorial Guinea Africa gene prevalence Article major clinical study adult artemisinin malaria falciparum Plasmodium falciparum
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065311511&doi=10.1128%2fAAC.01927-18&partnerID=40&md5=81845d28b02081de59e2582863017d22
DOI: 10.1128/AAC.01927-18
ISSN: 00664804
Original Language: English