Future Virology
Volume 14, Issue 8, 2019, Pages 509-514

A case of hepatitis B virus infection in Eritrean Diciotti migrant: phylogenetic analysis and 'mirror effect' (Article)

Ceccarelli G. , Cella E. , Vita S. , Lai A. , Ebranati E. , Zehender G. , Fogolari M. , Antonelli F. , Luca Guarino M.P. , Riva E. , Angeletti S.* , Ciccozzi M.
  • a Migrant Health Research Organisation (Mi-HeRO), Centro di Ricerca Sulla Salute delle Popolazioni Mobili e Globale, Italy, Department of Public Health and Infectious Diseases, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy, Sanitary Bureau of Extraordinary Reception Center for Mondo Migliore of Rocca di Papa, Rome, Italy, San Filippo Neri Coop. Soc. Onlus, Italy
  • b Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-medico of Rome, Italy
  • c Migrant Health Research Organisation (Mi-HeRO), Centro di Ricerca Sulla Salute delle Popolazioni Mobili e Globale, Italy, Infectious Diseases Unit, Ospedale S Maria Goretti, Latina, Italy
  • d Department of Biomedical and Clinical 'L Sacco', University of Milan, Milan, Italy
  • e Department of Biomedical and Clinical 'L Sacco', University of Milan, Milan, Italy
  • f Department of Biomedical and Clinical 'L Sacco', University of Milan, Milan, Italy
  • g Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Italy
  • h Unit of Gastroenterology, University Campus Bio-Medico of Rome, Italy
  • i Unit of Gastroenterology, University Campus Bio-Medico of Rome, Italy
  • j Unit of Virology, University Campus Bio-Medico of Rome, Italy
  • k Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Italy
  • l Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-medico of Rome, Italy

Abstract

A case of hepatitis B virus (HBV) infection in an Eritrean migrant was described to provide an epidemiological approach based on phylogenetic analysis useful in developing countries with lacking information. Migrant, positive for HBsAg and HBeAg, carried HBV at high copy number. A sequence of HBV HBsAg region was used for phylogenetic relationships and genetic variability investigation. In the phylogenetic tree, the sequence corresponded to D2 HBV genotype and the cluster root dated 7 years ago. These data compared with the date of landing in Italy, suggest that he was infected at least 7 years before his arrival. This approach by 'mirror effect' allows the reconstruction of HBV epidemiology in the country of origin, analyzing the migrant population in the host country. © 2019 Future Medicine Ltd.

Author Keywords

Phylogenetic analysis Eritrean migrant diciotti HBV D2 genotype HBV sequencing Epidemiology

Index Keywords

genotype developing country genetic variability human priority journal nonhuman Hepatitis B virus migrant Epidemiological Monitoring male case report virus genome clinical article Article Eritrean Phylogeny adult gene sequence hepatitis B surface antigen genome analysis hepatitis B phylogenetic tree hepatitis B(e) antigen
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072554723&doi=10.2217%2ffvl-2019-0034&partnerID=40&md5=615ac086880ea56c3c1fce6c1009e996
DOI: 10.2217/fvl-2019-0034
ISSN: 17460794
Original Language: English