Latent and active tuberculosis infections in migrants and travellers: A retrospective analysis from the Spanish +REDIVI collaborative network

Travel Medicine and Infectious Disease
2019

Latent and active tuberculosis infections in migrants and travellers: A retrospective analysis from the Spanish +REDIVI collaborative network (Article)

Wikman-Jorgensen P.* , López-Velez R. , Llenas-García J. , Treviño B. , Pascual R. , Molina I. , Domínguez Á. , Torrús D. , Ruiz Giardín J.M. , Monge-Maillo B. , Norman F.F. , Romero M. , Perez-Molina J.A. , Aguilera P. , Serrano M.M. , Rodriguez M.G. , Menendez M.D. , Meije Y. , Martínez-Montauti J. , Sanz X. , Tenza I.P. , Cuello I.G. , López B.M. , Masiá M. , Padilla S. , Ramos Rincón J.M. , Malmierca E. , Suárez-García I. , Perez-Ayala A. , Herrero J.M. , Lizasoain M. , Rojo P. , Zarco C. , Rodriguez-Guardado A. , Suárez J.F. , Boga Ribeiro J.A. , Agirre J.G. , Zubero Sulibarría M.Z. , Sanmartín López J.V. , Arribas M.V. , Muñoz E.C. , Ribas A.M. , Vera M.P. , Montalvá A.S. , Salvador F. , Moreno L. , Henríquez-Camacho C. , Delcor N.S. , Soriano-Arandes A. , Souto I.O. , Ciruelo D.P. , Bocanegra C. , +REDIVI Study Group

^a Hospital General Universitario de Elda, Alicante, Spain
^b National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramon y Cajal Hospital, IRYCIS, Madrid, Spain
^c Hospital Vega Baja, Orihuela, Alicante, Spain
^d Unitat Medicina Tropical i Salut Internacional Vall d'Hebron-Drassanes, PROSICS, Barcelona, Spain
^e Hospital General Universitario de Elda, Alicante, Spain, Departamento de Medicina Clinica, Universidad Miguel Hernández, San Juan de Alicante, Spain
^f Department of Infectious Diseases, Vall d'Hebron University Hospital, Universitat Autonoma de Barcelona, PROSICS Barcelona, Barcelona, Spain
^g Hospital Universitario Virgen de la Macarena de Sevilla, Sevilla, Spain
^h Hospital General Universitario de Alicante, Alicante, Spain
ⁱ Hospital Universitario de Fuenlabrada, Madrid, Spain
^j National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramon y Cajal Hospital, IRYCIS, Madrid, Spain
^k National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramon y Cajal Hospital, IRYCIS, Madrid, Spain
^l Hospital General Universitario de Elda, Alicante, Spain
^m National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramon y Cajal Hospital, IRYCIS, Madrid, Spain
ⁿ Centro de Atención Primaria Guayaba, Comunidad de Madrid, Spain
^o Complejo Hospitalario Universitario de Albacete, Comunidad de Castilla-La Mancha, Spain
^p Consorcio Hospital General Universitario de Valencia, Comunidad Valenciana, Spain
^q Hospital Carlos III-La Paz, Comunidad de Madrid, Spain
^r Hospital de Barcelona, Cataluña, Spain
^s Hospital de Barcelona, Cataluña, Spain
^t Hospital de Barcelona, Cataluña, Spain
^u Hospital de la Vega Baja de Orihuela, Comunidad Valenciana, Spain
^v Hospital de la Vega Baja de Orihuela, Comunidad Valenciana, Spain
^w Hospital de la Vega Baja de Orihuela, Comunidad Valenciana, Spain
^x Hospital General de Elche, Comunidad Valenciana, Spain
^y Hospital General de Elche, Comunidad Valenciana, Spain
^z Hospital General Universitario de Alicante, Comunidad Valenciana, Spain
^a Hospital Infanta Sofía, Comunidad de Madrid, Spain
^b Hospital Infanta Sofía, Comunidad de Madrid, Spain
^c Hospital Universitario 12 de Octubre, Madrid Comunidad de Madrid, Spain
^d Hospital Universitario 12 de Octubre, Madrid Comunidad de Madrid, Spain
^e Hospital Universitario 12 de Octubre, Madrid Comunidad de Madrid, Spain
^f Hospital Universitario 12 de Octubre, Madrid Comunidad de Madrid, Spain
^g Hospital Universitario 12 de Octubre, Madrid Comunidad de Madrid, Spain
^h Hospital Universitario Central de Asturias, Oviedo Principado de Asturias, Spain
ⁱ Hospital Universitario Central de Asturias, Oviedo Principado de Asturias, Spain
^j Hospital Universitario Central de Asturias, Oviedo Principado de Asturias, Spain
^k Hospital Universitario Cruces de Barakaldo, España País Vasco, Bilbao, Spain
^l Hospital Universitario de Basurto de Bilbao, País Vasco, Spain
^m Hospital Universitario de Fuenlabrada, Comunidad de Madrid, Spain
ⁿ Hospital Universitario Fundación de Alcorcón, Comunidad de Madrid, Spain
^o Hospital Universitario La Fe de Valencia, Comunidad Valenciana, Spain
^p Hospital Universitario Son Espases, Islas Baleares, Spain
^q Hospital Universitario Son Espases, Islas Baleares, Spain
^r Hospital Universitario Vall d'Hebron, Cataluña, Spain
^s Hospital Universitario Vall d'Hebron, Cataluña, Spain
^t Servicio de Enfermedades Infecciosas, Hospital Ramón y Cajal, Comunidad de Madrid, Spain
^u Servicio de Enfermedades Infecciosas, Hospital Ramón y Cajal, Comunidad de Madrid, Spain
^v Unitat de Salut Internacional Drassanes, PROSICS, Cataluña, Spain
^w Unitat de Salut Internacional Drassanes, PROSICS, Cataluña, Spain
^x Unitat de Salut Internacional Drassanes, PROSICS, Cataluña, Spain
^y Unitat de Salut Internacional Drassanes, PROSICS, Cataluña, Spain
^z Unitat de Salut Internacional Drassanes, PROSICS, Cataluña, Spain
^a [Affiliation not available]

Abstract

Background: Tuberculosis (TB) is the leading cause of infectious disease mortality worldwide. We analysed active and latent TB infections (LTBI) from the Spanish Network for the Study of Imported Infectious Diseases by Travellers and Immigrants (+REDIVI). Methods: Observational, retrospective, multicentre study of TB and LTBI registered in the +REDIVI network from October 2009 to December 2016. Results: Of 1008 cases of LTBI, 884 (87.7%) were immigrants; 93 (4.5%), immigrants visiting friends and relatives (VFR); 2 (0.9%), VFR-travellers; and 29 (1.1%), travellers. Absolute (N = 157 vs. N = 75) and relative (12.5% vs. 5.9%) frequency decreased over the study period (p = 0.003). Median time to diagnosis was 24.6 months (females 50.3 vs males 11.9; p < 0.001). Of 448 TB cases, 405 (90.4%) were in immigrants; 30 (6.7%), VFR-immigrants; 6 (1.3%), VFR-travellers; and 7 (1.6%), travellers. Median time to diagnosis was 62.5 months (females 86.6 vs males 70.1; p = 0.0075). There were 8 multidrug resistant TB cases and 1 extensively drug resistant case of TB, all in immigrants. Conclusion: TB was frequently diagnosed more than 5 years after arrival in Spain. Screening programmes for TB and LTBI in immigrants should be considered beyond this time point. Women showed a higher diagnostic delay for both latent and active TB. © 2019 Elsevier Ltd

Author Keywords

emigrants and immigrants tuberculosis travel Latent tuberculosis Travel-related illness

Index Keywords

[No Keywords available]

Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070322886&doi=10.1016%2fj.tmaid.2019.07.016&partnerID=40&md5=d18e7f67382592b5e364aa7a7ae2ab37

DOI: 10.1016/j.tmaid.2019.07.016

ISSN: 14778939

Original Language: English