Digestive Diseases
Volume 34, Issue 6, 2016, Pages 665-670

Coffee intake and liver enzyme association in Korean immigrants and Japanese: A comprehensive cross-sectional study (Article)

Kim S.K. , Shin M.-H.* , Sugimoto K. , Kim S.R. , Imoto S. , Kim K.I. , Taniguchi M. , Oh H.-K. , Yano Y. , Hayashi Y. , Kudo M.
  • a Department of Gastroenterology, Kobe Asahi Hospital, Kobe, Japan
  • b Department of Social and Preventive Medicine, Sungkyunkwan University, School of Medicine, 300 Chunchun-dong, Jangan-gu, Suwon, 440-746, South Korea
  • c Department of Pharmacy, Kobe Asahi Hospital, Kobe, Japan, Division of Molecular Medicine and Medical Genetics, Kobe University, Graduate School of Medicine, Kobe, Japan
  • d Department of Gastroenterology, Kobe Asahi Hospital, Kobe, Japan
  • e Department of Gastroenterology, Kobe Asahi Hospital, Kobe, Japan
  • f Department of Pharmacy, Kobe Asahi Hospital, Kobe, Japan
  • g Department of Gastroenterology, Kobe Asahi Hospital, Kobe, Japan
  • h Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, South Korea
  • i Division of Center Infectious Diseases, Kobe University, Graduate School of Medicine, Kobe, Japan
  • j Division of Molecular Medicine and Medical Genetics, Kobe University, Graduate School of Medicine, Kobe, Japan
  • k Department of Gastroenterology and Hepatology, Kindai University, Faculty of Medicine, Osaka-Sayama, Japan

Abstract

Objectives: Significant inverse association between coffee intake and the levels of liver enzymes has been reported. We demonstrated higher prevalence of metabolic syndrome in Korean immigrants (KIs) than in indigenous Japanese (IJs). The aim of this study was to investigate whether the association between coffee intake and liver enzyme levels was different between the 2 ethnic groups. Methods: This study is a cross-sectional study including a total of 966 subjects comprising KIs and IJs. The association between the quintiles of coffee intake and dichotomous values of liver enzymes was evaluated by logistic regression analysis in KIs, IJs, a high-risk group (current smokers or alcohol drinkers ≥45 g/day), and a low-risk group (non-smokers and alcohol drinkers <45 g/day). Results: In KIs, a significant inverse association between coffee intake and serum aspartate aminotransferase (AST) levels was observed. In the IJs, a significant inverse association between coffee intake and serum alanine aminotransferase levels was observed. In the high-risk group, a significant inverse association between coffee intake and serum AST and gamma-glutamyltransferase levels was observed. Conclusion: No difference was observed between KIs and IJs regarding the association between coffee and liver enzymes. Coffee might inhibit hepatic damage by alcohol drinking and smoking. © 2016 S. Karger AG, Basel.

Author Keywords

Coffee intake Indigenous Japanese Alcohol drinking and smoking Liver enzymes Korean immigrants

Index Keywords

South Korea immigrant Republic of Korea Alcohol Drinking Alanine Transaminase alanine aminotransferase blood level drinking behavior metabolic syndrome X alcohol consumption Korean (people) indigenous people alanine aminotransferase human sex difference Cohort Studies controlled study priority journal comparative study drinking gamma-Glutamyltransferase Japanese (people) ethnology normal value gamma glutamyl transferase blood level Aspartate Aminotransferases liver enzyme coffee Cross-Sectional Studies liver function test cross-sectional study migrant ethnic difference gamma glutamyltransferase smoking Humans male Japan Emigrants and Immigrants female Liver Function Tests risk factor Liver Risk Factors high risk population prevalence Article blood enzymology major clinical study low risk population aspartate aminotransferase cohort analysis aspartate aminotransferase blood level
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84992206872&doi=10.1159%2f000448832&partnerID=40&md5=42d27b1cf88d591eaa5aad1b5715dccd
DOI: 10.1159/000448832
ISSN: 02572753
Cited by: 2
Original Language: English