JAMA Internal Medicine
Volume 176, Issue 8, 2016, Pages 1146-1154

Association between socioeconomic status and mortality, cardiovascular disease, and cancer in patients with type 2 diabetes (Article) (Open Access)

Rawshani A.* , Svensson A.-M. , Zethelius B. , Eliasson B. , Rosengren A. , Gudbjörnsdottir S.
  • a Institute of Medicine, Department of Clinical and Molecular Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden, National Diabetes Register, Centre of Registers, Västra Götaland Region, Gothenburg, SE-41345, Sweden
  • b National Diabetes Register, Centre of Registers, Västra Götaland Region, Gothenburg, SE-41345, Sweden, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
  • c Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden, Medical Products Agency, Section for Epidemiology, Uppsala, Sweden
  • d Institute of Medicine, Department of Clinical and Molecular Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
  • e Institute of Medicine, Department of Clinical and Molecular Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden, National Diabetes Register, Centre of Registers, Västra Götaland Region, Gothenburg, SE-41345, Sweden
  • f National Diabetes Register, Centre of Registers, Västra Götaland Region, Gothenburg, SE-41345, Sweden, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden

Abstract

Importance: The association between socioeconomic status and survival based on all-cause, cardiovascular (CV), diabetes-related, and cancer mortality in type 2 diabetes has not been examined in a setting of persons with equitable access to health care with adjustment for important confounders. Objective: To determine whether income, educational level, marital status, and country of birth are independently associated with all-cause, CV, diabetes-related, and cancer mortality in persons with type 2 diabetes. Design, Setting, and Participants: A study including all 217 364 individuals younger than 70 years with type 2 diabetes in the Sweden National Diabetes Register (January 1, 2003, to December 31, 2010) who were monitored through December 31, 2012, was conducted. A Cox proportional hazards regression model with up to 17 covariates was used for analysis. Main Outcomes and Measures: All-cause, CV, diabetes-related, and cancer mortality. Results: Of the 217 364 persons included in the study, mean (SD) age was 58.3 (9.3) years and 130 839 of the population (60.2%) was male. There were a total of 19 105 all-cause deaths with 11 423 (59.8%), 6984 (36.6%), and 6438 (33.7%) CV, diabetes-related, or cancer deaths, respectively. Compared with being single, hazard ratios (HRs) for married individuals, determined using fully adjusted models, for all-cause, CV, and diabetes-related mortality were 0.73 (95%CI, 0.70-0.77), 0.67 (95%CI, 0.63-0.71), and 0.62 (95%CI, 0.57-0.67), respectively. Marital status was not associated with overall cancer mortality, but married men had a 33% lower risk of prostate cancer mortality compared with single men, with an HR of 0.67 (95%CI, 0.50-0.90). Comparison of HRs for the lowest vs highest income quintiles for all-cause, CV, diabetes-related, and cancer mortality were 1.71 (95%CI, 1.60-1.83), 1.87 (95% CI, 1.72-2.05), 1.80 (95%CI, 1.61-2.01), and 1.28 (95%CI, 1.14-1.44), respectively. Compared with native Swedes, HRs for all-cause, CV, diabetes-related, and cancer mortality for non-Western immigrants were 0.55 (95%CI, 0.48-0.63), 0.46 (95%CI, 0.38-0.56), 0.38 (95%CI, 0.29-0.49), and 0.72 (95%CI, 0.58-0.88), respectively, and these HRs were virtually unaffected by covariate adjustment. Hazard ratios for those with a college/university degree compared with 9 years or less of education were 0.85 (95%CI, 0.80-0.90), 0.84 (95%CI, 0.78-0.91), and 0.84 (95%CI, 0.76-0.93) for all-cause, CV, and cancer mortality, respectively. Conclusions and Relevance: Independent of risk factors, access to health care, and use of health care, socioeconomic status is a powerful predictor of all-cause and CV mortality but was not as strong as a predictor of death from cancer. © 2016 American Medical Association. All Rights Reserved.

Author Keywords

[No Keywords available]

Index Keywords

trachea cancer biliary tract cancer urinary tract cancer widowed person educational status immigrant South and Central America breast cancer cancer patient insulin dependent diabetes mellitus neoplasm non insulin dependent diabetes mellitus prostate cancer Follow-Up Studies sex ratio Neoplasms human follow up middle aged Middle East Odds Ratio statistics and numerical data Confidence Intervals priority journal health status Aged digestive system cancer albuminuria marriage Confidence interval diabetic patient income social status South Asia Diabetes Mellitus, Type 1 cardiovascular disease Sweden married person male Humans female Socioeconomic Factors risk factor Risk Factors Age of Onset socioeconomics pancreas cancer Caribbean Article cancer mortality liver cancer kidney cancer major clinical study adult North Africa Sex Distribution cardiovascular mortality cohort analysis divorced person onset age coronary artery disease mortality Health Services Accessibility health care delivery

Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84980344033&doi=10.1001%2fjamainternmed.2016.2940&partnerID=40&md5=d1c262935120283bccad374acbf9decc

DOI: 10.1001/jamainternmed.2016.2940
ISSN: 21686106
Cited by: 31
Original Language: English