JAMA Internal Medicine
Volume 176, Issue 8, 2016, Pages 1146-1154
Association between socioeconomic status and mortality, cardiovascular disease, and cancer in patients with type 2 diabetes (Article) (Open Access)
Rawshani A.* ,
Svensson A.-M. ,
Zethelius B. ,
Eliasson B. ,
Rosengren A. ,
Gudbjörnsdottir S.
-
a
Institute of Medicine, Department of Clinical and Molecular Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden, National Diabetes Register, Centre of Registers, Västra Götaland Region, Gothenburg, SE-41345, Sweden
-
b
National Diabetes Register, Centre of Registers, Västra Götaland Region, Gothenburg, SE-41345, Sweden, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
-
c
Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden, Medical Products Agency, Section for Epidemiology, Uppsala, Sweden
-
d
Institute of Medicine, Department of Clinical and Molecular Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
-
e
Institute of Medicine, Department of Clinical and Molecular Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden, National Diabetes Register, Centre of Registers, Västra Götaland Region, Gothenburg, SE-41345, Sweden
-
f
National Diabetes Register, Centre of Registers, Västra Götaland Region, Gothenburg, SE-41345, Sweden, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden
Abstract
Importance: The association between socioeconomic status and survival based on all-cause, cardiovascular (CV), diabetes-related, and cancer mortality in type 2 diabetes has not been examined in a setting of persons with equitable access to health care with adjustment for important confounders. Objective: To determine whether income, educational level, marital status, and country of birth are independently associated with all-cause, CV, diabetes-related, and cancer mortality in persons with type 2 diabetes. Design, Setting, and Participants: A study including all 217 364 individuals younger than 70 years with type 2 diabetes in the Sweden National Diabetes Register (January 1, 2003, to December 31, 2010) who were monitored through December 31, 2012, was conducted. A Cox proportional hazards regression model with up to 17 covariates was used for analysis. Main Outcomes and Measures: All-cause, CV, diabetes-related, and cancer mortality. Results: Of the 217 364 persons included in the study, mean (SD) age was 58.3 (9.3) years and 130 839 of the population (60.2%) was male. There were a total of 19 105 all-cause deaths with 11 423 (59.8%), 6984 (36.6%), and 6438 (33.7%) CV, diabetes-related, or cancer deaths, respectively. Compared with being single, hazard ratios (HRs) for married individuals, determined using fully adjusted models, for all-cause, CV, and diabetes-related mortality were 0.73 (95%CI, 0.70-0.77), 0.67 (95%CI, 0.63-0.71), and 0.62 (95%CI, 0.57-0.67), respectively. Marital status was not associated with overall cancer mortality, but married men had a 33% lower risk of prostate cancer mortality compared with single men, with an HR of 0.67 (95%CI, 0.50-0.90). Comparison of HRs for the lowest vs highest income quintiles for all-cause, CV, diabetes-related, and cancer mortality were 1.71 (95%CI, 1.60-1.83), 1.87 (95% CI, 1.72-2.05), 1.80 (95%CI, 1.61-2.01), and 1.28 (95%CI, 1.14-1.44), respectively. Compared with native Swedes, HRs for all-cause, CV, diabetes-related, and cancer mortality for non-Western immigrants were 0.55 (95%CI, 0.48-0.63), 0.46 (95%CI, 0.38-0.56), 0.38 (95%CI, 0.29-0.49), and 0.72 (95%CI, 0.58-0.88), respectively, and these HRs were virtually unaffected by covariate adjustment. Hazard ratios for those with a college/university degree compared with 9 years or less of education were 0.85 (95%CI, 0.80-0.90), 0.84 (95%CI, 0.78-0.91), and 0.84 (95%CI, 0.76-0.93) for all-cause, CV, and cancer mortality, respectively. Conclusions and Relevance: Independent of risk factors, access to health care, and use of health care, socioeconomic status is a powerful predictor of all-cause and CV mortality but was not as strong as a predictor of death from cancer. © 2016 American Medical Association. All Rights Reserved.
Author Keywords
[No Keywords available]
Index Keywords
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84980344033&doi=10.1001%2fjamainternmed.2016.2940&partnerID=40&md5=d1c262935120283bccad374acbf9decc
DOI: 10.1001/jamainternmed.2016.2940
ISSN: 21686106
Cited by: 31
Original Language: English