Archivos de Bronconeumologia
Volume 52, Issue 6, 2016, Pages 289-292

Outbreak of isoniazid-resistant tuberculosis in an immigrant community in Spain [Brote de tuberculosis resistente a isoniacida en una comunidad de inmigrantes en España] (Article)

Hernán García C.* , Moreno Cea L. , Fernández Espinilla V. , Ruiz Lopez del Prado G. , Fernández Arribas S. , Andrés García I. , Rubio V. , Vesenbeckh S. , Eiros Bouza J.M.
  • a Servicio de Medicina Preventiva y Salud Publica, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
  • b Servicio de Medicina Preventiva y Salud Publica, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
  • c Servicio de Medicina Preventiva y Salud Publica, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
  • d Servicio de Medicina Preventiva y Salud Publica, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
  • e Servicio de Epidemiología, Dirección General de Salud Pública, Consejería de Sanidad, Valladolid, Spain
  • f Servicio de Medicina Preventiva y Salud Publica, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
  • g Servicio de Medicina Preventiva y Salud Publica, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
  • h Department of Respiratory Medicine, HELIOS Klinikum Emil von Behring, Berlín, Alemania, Germany
  • i Hospital Clínico Universitario de Valladolid, Valladolid, Spain

Abstract

Background: Tuberculosis (TB) remains a major public health problem. In 2013, 9 million new cases of active TB were estimated globally and the proportion of reported new cases with multi-drug resistance (MDR) was 3.5%. Methods: Contact tracing of a case of pulmonary tuberculosis was performed in a Bolivian patient. Diagnostic tests were performed according to national and local protocols. Results: An outbreak of tuberculosis in an immigrant community was detected, with 5 cases originating from one index case. Genotyping and drug susceptibility testing of the sputum samples determined Mycobacterium tuberculosis resistant to isoniazid (KatG-msp unmutated/inhA 5 RBS CT). Active case finding revealed a total of 39 contacts with an incidence of latent infection of 71.43%. Conclusions: The present study confirms the importance of active case finding through contact tracing as well as rapid laboratory diagnosis to achieve improvements in early detection of TB. Early diagnosis of the patient, compliance with appropriate treatment protocols and monitoring of drug resistance are considered essential for the prevention and control of TB. © 2015 SEPAR.

Author Keywords

Drug-resistant tuberculosis outbreak Contact tracing Latent tuberculosis Immigration

Index Keywords

tuberculous pleurisy genetics Tuberculosis, Pleural genotype clinical protocol immigrant transmission drug effects follow up human interferon gamma release assay multidrug resistant tuberculosis Mycobacterium tuberculosis Interferon-gamma Release Tests controlled study Tuberculosis, Multidrug-Resistant BCG vaccine nonhuman ethnology Bolivian drug resistant tuberculosis Humans migrant lung tuberculosis tuberculostatic agent Antitubercular Agents male Emigrants and Immigrants Tuberculosis, Pulmonary latent tuberculosis preschool child sputum analysis risk factor sputum examination Spain female diagnostic test contact examination genotyping technique clinical article isolation and purification Disease Outbreaks Contact Tracing Article epidemic Incidence patient compliance drug sensitivity tuberculin test adult isoniazid antibiotic sensitivity tuberculosis control ethambutol tuberculosis rapid test rifampicin Bolivia bacterial strain pyrazinamide Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85027234095&doi=10.1016%2fj.arbr.2016.02.006&partnerID=40&md5=625ab98984938d7c40f15f2a821261b1
DOI: 10.1016/j.arbr.2016.02.006
ISSN: 03002896
Cited by: 2
Original Language: Spanish