American Journal of Respiratory and Critical Care Medicine
Volume 193, Issue 3, 2016, Pages 337-340

Delamanid and bedaquiline resistance in mycobacterium tuberculosis ancestral Beijing genotype causing extensively drug-resistant tuberculosis in a tibetan refugee (Letter)

Hoffmann H. , Kohl T.A. , Hofmann-Thiel S. , Merker M. , Beckert P. , Jaton K. , Nedialkova L. , Sahalchyk E. , Rothe T. , Keller P.M. , Niemann S.
  • a Synlab MVZ Gauting, Munich-Gauting, Germany, World Health Organization Supranational Reference Laboratory of Tuberculosis, Munich-Gauting, Germany
  • b Leibniz-Zentrum fur Medizin und Biowissenschaften, Borstel, Germany
  • c Synlab MVZ Gauting, Munich-Gauting, Germany, World Health Organization Supranational Reference Laboratory of Tuberculosis, Munich-Gauting, Germany
  • d Leibniz-Zentrum fur Medizin und Biowissenschaften, Borstel, Germany, German Center for Infection Research, Borstel, Germany
  • e Leibniz-Zentrum fur Medizin und Biowissenschaften, Borstel, Germany, German Center for Infection Research, Borstel, Germany
  • f University Hospital Lausanne, Lausanne, Switzerland
  • g World Health Organization Supranational Reference Laboratory of Tuberculosis, Munich-Gauting, Germany
  • h World Health Organization Supranational Reference Laboratory of Tuberculosis, Munich-Gauting, Germany
  • i Zurcher Hohenklinik Davos, Davos Clavadel, Switzerland
  • j Institut fur Medizinische Mikrobiologie, Zurich, Switzerland
  • k Leibniz-Zentrum fur Medizin und Biowissenschaften, Borstel, Germany

Abstract

[No abstract available]

Author Keywords

[No Keywords available]

Index Keywords

genetics genotype China Tibet maximum likelihood method Extensively Drug-Resistant Tuberculosis refugee drug effects aminosalicylic acid capreomycin Letter concentration response drug treatment failure genetic variability human Refugees minimum inhibitory concentration controlled study Mycobacterium tuberculosis priority journal Tibetan (people) ethnology plesiomorphy nitroimidazole derivative regulator gene Diarylquinolines Oxazoles fbia gene Drug Resistance, Multiple, Bacterial quinoline derivative Compassionate Use Trials bedaquiline delamanid Humans lung lobectomy compassionate use next generation sequencing tuberculostatic agent Antitubercular Agents male Nitroimidazoles case report OPC-67683 oxazole derivative cross resistance Beijing mutator gene cycloserine cotrimoxazole drug substitution drug withdrawal gene mutation bacterial gene multidrug resistance antibiotic therapy adult Amikacin Clofazimine antibiotic sensitivity extensively drug resistant tuberculosis microbiology antibiotic resistance ethambutol bacterium isolate bacterial genome levofloxacin
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84973911525&doi=10.1164%2frccm.201502-0372LE&partnerID=40&md5=2e022f98264db04cc7b4acdf8fdc8696
DOI: 10.1164/rccm.201502-0372LE
ISSN: 1073449X
Cited by: 44
Original Language: English