Scientific Reports
Volume 8, Issue 1, 2018

Addressing the impact of urban exposure on the incidence of type 2 diabetes mellitus: The Peru MIGRANT Study (Article) (Open Access)

Ruiz-Alejos A. , Carrillo-Larco R.M. , Miranda J.J. , Anderson C.A.M. , Gilman R.H. , Smeeth L. , Bernabé-Ortiz A.*
  • a CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru
  • b CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru
  • c CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru, Department of Medicine, School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru
  • d Department of Family Medicine and Public Health, School of Medicine, University of California San Diego, California, United States
  • e CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, United States
  • f Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
  • g CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom

Abstract

The aim of this study was to estimate the incidence of T2DM in three population groups: rural, rural-to-urban migrants and urban dwellers. Data from the Peru MIGRANT Study was analysed. The baseline assessment was conducted in 2007-2008 using a single-stage random sample and further follow-up was undertaken in 2015-16. T2DM was defined based on fasting glucose and self-reported diagnosis. Poisson regression models and robust variance to account for cluster effects were used for reporting risk ratios (RR) and 95%CI. At baseline, T2DM prevalence was 8% in urban, 3.6% in rural-to-urban migrants and 1.5% in rural dwellers. After 7.7 (SD: 1.1) years, 6,076 person-years of follow-up, 61 new cases were identified. The incidence rates in the urban, migrant and rural groups were 1.6, 0.9 and 0.5 per 100 person-years, respectively. Relative to rural dwellers, a 4.3-fold higher risk (95%CI: 1.6-11.9) for developing T2DM was found in urban dwellers and 2.7-fold higher (95%CI: 1.1-6.8) in migrants with ≥30 years of urban exposure. Migration and urban exposure were found as significant risk factors for developing T2DM. Within-country migration is a sociodemographic phenomenon occurring worldwide; thus, it is necessary to disentangle the effect of urban exposure on non-healthy habits and T2DM development. © 2018 The Author(s).

Author Keywords

[No Keywords available]

Index Keywords

male urban population female risk factor Risk Factors Humans Transients and Migrants Incidence non insulin dependent diabetes mellitus Diabetes Mellitus, Type 2 human adult migration
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044954804&doi=10.1038%2fs41598-018-23812-6&partnerID=40&md5=6684eb4e2fade025940dafc7b2de9052
DOI: 10.1038/s41598-018-23812-6
ISSN: 20452322
Cited by: 4
Original Language: English