International Journal of Tuberculosis and Lung Disease
Volume 14, Issue 11, 2010, Pages 1411-1417

Predictors of failure to complete tuberculosis treatment in London, 2003-2006 (Article)

Cegolon L.* , Maguire H. , Mastrangelo G. , Carless J. , Kruijshaar M.E. , Verlander N.Q.
  • a London Regional Epidemiology Unit, Health Protection Agency, 330 High Holborn, London WC1V 7PP, United Kingdom, Department of Environmental Medicine and Public Health, University of Padua, Padua, Italy, School of Public Health, Imperial College, London, United Kingdom
  • b London Regional Epidemiology Unit, Health Protection Agency, 330 High Holborn, London WC1V 7PP, United Kingdom, St George's Hospital Medical School, London, United Kingdom
  • c Department of Environmental Medicine and Public Health, University of Padua, Padua, Italy
  • d London Regional Epidemiology Unit, Health Protection Agency, 330 High Holborn, London WC1V 7PP, United Kingdom
  • e Centre for Infections, Health Protection Agency, London, United Kingdom
  • f Centre for Infections, Health Protection Agency, London, United Kingdom

Abstract

SETTING: London, 2003-2006. OBJECTIVES: To investigate tuberculosis (TB) treatment completion failure in London and associated risk factors during 2003-2006. DESIGN: Cross-sectional analysis of treatment outcome and other explanatory variables in a cohort of TB patients reported to the London TB Register from 2003 to 2006. METHODS: An innovative definition of TB treatment outcome more suitable for low-incidence industrialised countries, such as the United Kingdom, was adopted. A multivariable logistic approach was used to assess predictors of unsuccessful outcome. RESULTS: A total of 12 929 TB cases were notified from 2003 to 2006, of which 12% (n = 1536) failed to complete TB treatment. The proportion of cases failing to complete treatment showed a significant decrease from 2003 to 2006 (13% in 2003 vs. 10% in 2006). Males, the elderly, hospitalised patients, short- and long-term immigrants, Whites and the least deprived were more likely to fail to complete treatment. CONCLUSIONS: The proportion of TB treatment success in London exceeded the World Health Organization recommended threshold of 85%. Some specific categories of patients that are more likely to fail to complete treatment should be targeted by health services to enhance their engagement and adherence to the treatment regimen. © 2010 The Union.

Author Keywords

Socio-economic deprivation Surveillance London Tuberculosis treatment completion

Index Keywords

immigrant hospital patient Registries race difference drug treatment failure Follow-Up Studies London human trend study sex difference middle aged priority journal Aged Logistic Models nonhuman groups by age Cross-Sectional Studies predictor variable Young Adult school child social status Humans Treatment Outcome Antitubercular Agents Adolescent male preschool child female tuberculosis risk factor Infant Risk Factors Child, Preschool Multivariate Analysis Article patient compliance major clinical study adult antibiotic therapy Sex Factors Age Factors United Kingdom treatment refusal Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-78049449508&partnerID=40&md5=bda7c7fd2141492377e6e67561ee00e4
ISSN: 10273719
Cited by: 10
Original Language: English