European Respiratory Journal
Volume 51, Issue 1, 2018

National roll-out of latent tuberculosis testing and treatment for new migrants in England: A retrospective evaluation in a high-incidence area (Article) (Open Access)

Loutet M.G.* , Burman M. , Jayasekera N. , Trathen D. , Dart S. , Kunst H. , Zenner D.
  • a National Infection Service, Public Health England, London, United Kingdom
  • b Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, United Kingdom, Dept of Respiratory Medicine, Barts Health NHS Trust, London, United Kingdom
  • c Dept of Respiratory Medicine, Barts Health NHS Trust, London, United Kingdom
  • d Newham Clinical Commissioning Group, London, United Kingdom
  • e Dept of Respiratory Medicine, Barts Health NHS Trust, London, United Kingdom
  • f Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, United Kingdom, Dept of Respiratory Medicine, Barts Health NHS Trust, London, United Kingdom
  • g National Infection Service, Public Health England, London, United Kingdom, Institute for Global Health, University College London, London, United Kingdom, National Institute for Health Research Health Protection Research Unit in Respiratory Infections, Imperial College London, London, United Kingdom

Abstract

Latent tuberculosis infection (LTBI) screening is an important intervention for tuberculosis (TB) elimination in low-incidence countries and is, therefore, a key component of England’s TB control strategy. This study describes outcomes from a LTBI screening programme in a high-incidence area to inform national LTBI screening in England and other low-incidence countries. We conducted a retrospective cohort study of LTBI screening among eligible migrants (from high-incidence countries and entered the UK within the last 5 years), who were identified at primary-care clinics in Newham, London between August 2014 and August 2015. Multivariable logistic regression was used to identify factors associated with LTBI testing uptake, interferon-γ release assay (IGRA) positivity and treatment uptake. 40% of individuals offered LTBI screening received an IGRA test. The majority of individuals tested were 16–35 years old, male and born in India, Bangladesh or Pakistan. Country of birth, smoking status and co-morbidities were associated with LTBI testing uptake. IGRA positivity was 32% among those tested and was significantly associated with country of birth, age, sex and co-morbidities. This study identifies factors associated with screening uptake, IGRA positivity and treatment uptake, and improves understanding of groups that should be supported to increase acceptability of LTBI testing and treatment in the community. Copyright ©ERS 2018.

Author Keywords

[No Keywords available]

Index Keywords

Pakistan infectious disease medicine birth primary medical care India predictive value human infection rate comorbidity middle aged interferon gamma release assay Interferon-gamma Release Tests priority journal procedures Young Adult Humans migrant Adolescent male England latent tuberculosis female communicable disease control Incidence Article Retrospective Studies major clinical study tuberculin test adult migration Predictive Value of Tests age United Kingdom Bangladesh Transients and Migrants retrospective study sex smoking habit
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85057563068&doi=10.1183%2f13993003.01226-2017&partnerID=40&md5=960ea17c7b908edaf99c8654aafe3497
DOI: 10.1183/13993003.01226-2017
ISSN: 09031936
Cited by: 4
Original Language: English