Human Immunology
Volume 67, Issue 7, 2006, Pages 540-550

HLA Alleles and Haplotypes in French North African Immigrants (Article)

Pédron B. , Yakouben K. , Guérin V. , Borsali E. , Auvrignon A. , Landman J. , Alberti C. , Leverger G. , Baruchel A. , Sterkers G.*
  • a Laboratory of Immunology, Hôpital Robert Debré, Paris, France
  • b Department of Hematology, Hôpital Robert Debré, Paris, France
  • c Laboratory of Immunology, Hôpital Robert Debré, Paris, France
  • d Laboratory of Immunology, Hôpital Robert Debré, Paris, France
  • e Department of Hematology, Hôpital Trousseau, Paris, France
  • f Department of Hematology, Hôpital Trousseau, Paris, France
  • g Unit of Clinical Epidemiology, INSERM CIE 5, Hôpital Robert Debré, Paris, France
  • h Department of Hematology, Hôpital Trousseau, Paris, France
  • i Department of Hematology, Hôpital Saint-Louis, Paris, France
  • j Laboratory of Immunology, Hôpital Robert Debré, Paris, France

Abstract

Human leukocyte antigen (HLA) haplotypes (n = 187) were genotyped and assigned by the mode of inheritance in migrant families from North Africa who reside in the Paris, France, area. The distribution of alleles and haplotypes in that population was compared with the one obtained in a control population of ancient French natives residing in the same area (248 independent haplotypes also assigned by the mode of inheritance were studied). The results in migrants reveal the following: (1) a higher diversity in the distribution of HLA-A and -DRB1 alleles; (2) lower frequencies of alleles common in our region, such as A*0201 B*1501, B*4001, and DRB1*0401 and increased frequencies of minor subtypes, such as A*3002 and DRB1*0402; and (3) distinct distributions of B/Cw, DRB1/DQB1 or B/Cw/DRB1/DQB1 haplotypes. The results also revealed that the four most frequent five-allele haplotypes in controls i.e., HLA-A*0101/B*0801/Cw*0701/DRB1*0301/DQB1*0 201; A*0301/B*0702/Cw*0702/DRB1*1501/DQB1*0602 (both of Indo-Celtic origin); A*2902/B*4403/Cw*1601/DRB1*0701/DQB1*0202 (frequent in Western-Europeans); and A*0201/B*1501/Cw*0304/DRB1*0401/DQB1*0302, represent 10.5% of the total haplotypes in controls but 1.6% in North Africans. Conversely, 9 five-allele haplotypes in multiple copy in North Africans (among which A*3002/B*1801/Cw*0501/DRB1*0301/DQB1*0201 of Paleo-North African origin and A*0201/B*0702/Cw*0702/DRB1*1501/DQB1*0602 of ancient European and Paleo-North African origin) represent 9.6% of the total haplotypes in North Africans but 2.4% in controls. These results thus suggest a low degree of admixture between the two populations. © 2006 American Society for Histocompatibility and Immunogenetics.

Author Keywords

North Africans HLA

Index Keywords

genotype immigrant Europe France genetic variability human controlled study priority journal Western Europe haplotype male female HLA DQB1 antigen HLA antigen HLA Antigens inheritance HLA system Gene Frequency Article HLA DR antigen genetic analysis major clinical study Africa, Northern population genetics North Africa Haplotypes allele Paris Polymorphism, Genetic Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33745758370&doi=10.1016%2fj.humimm.2005.10.017&partnerID=40&md5=07a5fe3127a27619eb0d294da3da0964
DOI: 10.1016/j.humimm.2005.10.017
ISSN: 01988859
Cited by: 20
Original Language: English