Vaccine
Volume 24, Issue 23, 2006, Pages 4962-4968

Effectiveness of a hepatitis A vaccination program for migrant children in Amsterdam, The Netherlands (1992-2004) (Article)

Sonder G.J.B.* , Bovée L.P.M.J. , Baayen T.D. , Coutinho R.A. , van den Hoek J.A.R.
  • a GGD, Municipal Health Service Amsterdam, Department of Infectious Diseases, Nieuwe Achtergracht 100, PO Box 2200, 1000 CE Amsterdam, Netherlands, LCR, National Coordination Center for Travelers Health Advice, Nieuwe Achtergracht 100, PO Box 1008, 1000 BA Amsterdam, Netherlands
  • b GGD, Municipal Health Service Amsterdam, Department of Infectious Diseases, Nieuwe Achtergracht 100, PO Box 2200, 1000 CE Amsterdam, Netherlands
  • c GGD, Municipal Health Service Amsterdam, Department of Infectious Diseases, Nieuwe Achtergracht 100, PO Box 2200, 1000 CE Amsterdam, Netherlands
  • d GGD, Municipal Health Service Amsterdam, Department of Infectious Diseases, Nieuwe Achtergracht 100, PO Box 2200, 1000 CE Amsterdam, Netherlands, Academic Medical Center, University of Amsterdam, Department of Human Retrovirology, Meibergdreef 15, 1105 AZ Amsterdam, Netherlands
  • e GGD, Municipal Health Service Amsterdam, Department of Infectious Diseases, Nieuwe Achtergracht 100, PO Box 2200, 1000 CE Amsterdam, Netherlands

Abstract

Objective: To evaluate the impact and effectiveness of risk-group vaccination against hepatitis A targeted at migrant children living in a country with low endemicity of hepatitis A. Methods: Retrospective population based data analysis. Routinely collected data on hepatitis A incidence in migrant children and other risk groups in Amsterdam from 1 January 1992 to 2004 were analyzed and related to exposure, immunity and vaccination coverage in migrant children. Results: The overall hepatitis A incidence in Amsterdam declined after a pediatric vaccine was introduced in 1997. This decline was seen in migrant children traveling to hepatitis A-endemic countries, contacts with hepatitis A patients, primary school students, injecting drug users, and persons with unknown source of infection, but not in men who have sex with men (MSM) or in travelers to endemic countries other than migrant children. Conclusion: The hepatitis A vaccination campaigns are effective: they reduce both import and secondary HAV cases. The campaigns could be more efficient and cost-effective if the hepatitis B vaccinations currently given to these groups were replaced by a combined hepatitis A and B vaccine. This would increase the hepatitis A vaccination coverage considerably and further reduce the hepatitis A incidence. © 2006 Elsevier Ltd. All rights reserved.

Author Keywords

Hepatitis A Risk group Vaccination Migrant Children Epidemiology

Index Keywords

primary school Netherlands human hepatitis A travel controlled study priority journal Time Factors immunity Hepatitis A Vaccines cost effectiveness analysis health program Humans Adolescent Infant Child, Preschool high risk population population research injection Incidence drug targeting Article major clinical study migration Turkey endemic disease drug use Emigration and Immigration Immunization Programs retrospective study vaccination drug screening hepatitis A vaccine Morocco exposure Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33646893859&doi=10.1016%2fj.vaccine.2006.03.075&partnerID=40&md5=5895a61d51bcdaf857c9bed71714585d
DOI: 10.1016/j.vaccine.2006.03.075
ISSN: 0264410X
Cited by: 24
Original Language: English