Women suffering from anovulatory infertility may develop endometrial hyperplasia and adenocarcinoma due to the unopposed estrogen effect. We present the case of a young infertile woman with endometrial atypical hyperplasia bordering on adenocarcinoma who refused hysterectomy and bilateral salpingo-oophorectomy and achieved two successful pregnancies after conservative treatment with high-dose progesterone followed by in vitro fertilization and embryo transfer. It is concluded that conservative treatment with high-dose progesterone for endometrial hyperplasia and well-differentiated early-stage adenocarcinoma followed by assisted reproductive technologies is an appropriate means for achieving pregnancy. However, the issue of hysterectomy and bilateral salpingo-oophorectomy after delivery or after fertility being no longer required is controversial. If surgery is not performed, close observation with endometrial sampling every 6 months is advisable. Copyright © 2006 S. Karger AG.

Endometrial carcinoma Endometrial hyperplasia Assisted reproductive technologies Pregnancy Progesterone Infertility

drug megadose clinical feature human pregnancy rate priority journal Humans Treatment Outcome case report female pregnancy Article pregnancy outcome adult progesterone conservative treatment hysterectomy Fertilization in Vitro treatment refusal Infertility, Female Anovulation Adenocarcinoma endometrium carcinoma salpingooophorectomy endometrium hyperplasia Endometrial Hyperplasia embryo transfer Uterine Neoplasms