International Journal of Immunopathology and Pharmacology
Volume 19, Issue 3, 2006, Pages 629-638

Relationship between specific serum IGE to Ascaris lumbricoides and onset of respiratory symptoms in Bangladesh immigrants (Article)

Di Lorenzo G.* , Pacor M.L. , Mansueto P. , Esposito-Pellitteri M. , Scichilone N. , Ditta V. , Lo Bianco C. , Leto-Barone M.S. , Di Fede G. , Corrocher R. , Mansueto S. , Rini G.B.
  • a Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universitá degli Studi di Palermo, Italy, Dipartimento di Medicina Clinica e delle Patologie Emergenti, Via del Vespro 141, 90127 Palermo, Italy
  • b Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Verona, Italy
  • c Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universitá degli Studi di Palermo, Italy
  • d Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universitá degli Studi di Palermo, Italy
  • e Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell'Apparato Respiratorio, Università degli Studi di Palermo, Italy
  • f Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universitá degli Studi di Palermo, Italy
  • g Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universitá degli Studi di Palermo, Italy
  • h Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universitá degli Studi di Palermo, Italy
  • i Dipartimento di Discipline Chirurgiche ed Oncologiche, Università degli Studi di Palermo, Italy
  • j Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Verona, Italy
  • k Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universitá degli Studi di Palermo, Italy
  • l Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universitá degli Studi di Palermo, Italy

Abstract

The role of helminths in asthma and/or rhinitis and in allergic sensitization is still unclear. We assessed the relationship between Ascaris-specific IgE, respiratory symptoms and allergic sensitization in Bangladesh immigrants. 246 individuals were examined from 1996 to 2001. Serum total IgE, Ascaris IgE, specific IgE to inhalant allergens, skin prick tests (SPT) and parasitological evaluation of the stool were performed. Total serum IgE were significantly higher in Ascaris-IgE positive (> 0.35 kU/L) individuals (806.5 [409.0-1436.0] kU/L vs. 207.0 [127.0-332.5] kU/L; P < 0.0001) and in subjects with respiratory symptoms (413.0 [239.0-1096.0] kU/L vs. 259.5 [147.0-387.0] kU/L), (P < 0.0001), but not in SPT positive subjects (413.0 [179.0-894.0] kU/L vs. 404.6 [305.0-1201.0] kU/L (P = 0.5). Ascaris-specific IgE were detected in 48 subjects with respiratory symptoms (40.0%) and in 46 subjects without respiratory symptoms (36.5%) (P = 0.5). The SPT positivity was similar between Ascaris-IgE seropositive (38.2%) and Ascaris-IgE seronegative (38.1%) subjects (P = 0.9). Total IgE and length of stay in Italy correlated with SPT positivity (OR 5.6 [CI 95% 1.5-19.8], P = 0.007, and OR 1.5 [CI 95% 1.3-1.7], P < 0.0001), and with respiratory symptoms (OR 13.7 [CI 95% 3.0-62.4], P = 0.0007, and OR 2.4 [CI 95% 1.9-3.0], P < 0.0001). Ascaris-IgE were negatively associated with SPT positivity (OR 0.3 [CI 95% 0.1-0.8], P = 0.02) and with respiratory symptoms (OR 0.1 [CI 95% 0.04-0.7], P = 0.01). Our findings favour the role of environmental factors in the development of respiratory symptoms in immigrants, irrespective of Ascaris-IgE. Copyright © by Biolife, s.a.s.

Author Keywords

Allergen-specific IgE Ascaris-specific IgE Asthma rhinitis total serum IgE

Index Keywords

Ascaris lumbricoides male controlled study prick test female major clinical study immunoglobulin E priority journal environmental factor Bangladesh respiratory tract infection serodiagnosis Article human adult feces analysis
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33750072034&doi=10.1177%2f039463200601900319&partnerID=40&md5=5d74d85fe5850b52701c65699a95f8f5
DOI: 10.1177/039463200601900319
ISSN: 03946320
Cited by: 7
Original Language: English