International Journal of Tuberculosis and Lung Disease
Volume 14, Issue 9, 2010, Pages 1209-1211

Predictive values of QuantiFERON®-TB Gold testing in screening for tuberculosis disease in asylum seekers (Article)

Harstad I.* , Winje B.A. , Heldal E. , Oftung F. , Jacobsen G.W.
  • a Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway
  • b Norwegian Institute of Public Health, Oslo, Norway
  • c Norwegian Institute of Public Health, Oslo, Norway
  • d Norwegian Institute of Public Health, Oslo, Norway
  • e Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway

Abstract

Screening with chest X-ray and the Mantoux test (the tuberculin skin test [TST]) is compulsory for adult asylum seekers who arrive in Norway. In 2005-2006, we included 823 asylum seekers in a study of the QuantiFERON®-TB Gold test (QFT-G), and followed them for 23-32 months. Eight subjects with a positive and one with a negative QFT-G test were diagnosed with tuberculosis (TB). The positive (PPV) and negative predictive values (NPV) for TB were respectively 3.3% and 99.8%. The PPV was 2.3% and the NPV 99.1% for TST ≥ 15 mm, and the NPV was 99.5% for TST ≥ 6 mm in combination with a negative QFT-G. © 2010 The Union.

Author Keywords

QFT-G IGRA test Latent tuberculosis Refugee Predictive values

Index Keywords

refugee mass screening Norway Follow-Up Studies follow up human Refugees middle aged priority journal screening Young Adult Humans Adolescent male latent tuberculosis female tuberculosis gamma interferon Article major clinical study adult tuberculin test Predictive Value of Tests thorax radiography Interferon-gamma Reagent Kits, Diagnostic
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-77956569925&partnerID=40&md5=59eb8ac18602e61764f410713f3e7087
ISSN: 10273719
Cited by: 22
Original Language: English