Annals of Epidemiology
Volume 15, Issue 10, 2005, Pages 789-795

Dietary patterns and the risk of breast cancer (Article)

Adebamowo C.A.* , Hu F.B. , Cho E. , Spiegelman D. , Holmes M.D. , Willett W.C.
  • a Department of Nutrition, Harvard School of Public Health, Boston, MA, United States, Department of Surgery, University of Ibadan, University College Hospital, Ibadan, Oyo State, Nigeria, Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, United States
  • b Department of Nutrition, Harvard School of Public Health, Boston, MA, United States, Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
  • c Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
  • d Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States, Department of Biostatistics, Harvard School of Public Health, Boston, MA, United States
  • e Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
  • f Department of Nutrition, Harvard School of Public Health, Boston, MA, United States, Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States

Abstract

PURPOSE: Ecologic, migrant, and secular trend studies suggest an association between the Western diet and the risk of breast cancer. We examined data from the Nurses Health Study II to evaluate the association between major dietary patterns and the risk of breast cancer among pre-menopausal women. METHODS: We derived "Western" and "prudent" dietary patterns from the responses of 90,638 premenopausal women, aged 26 to 46 years at baseline in 1991, who completed validated food frequency questionnaires in 1991 and 1995. These patterns were then evaluated for their associations with risk of breast cancer. RESULTS: During 8 years of follow-up, we documented 710 cases of invasive breast cancer. The multivariate RR (95% CI) comparing highest to lowest quintiles of cumulative average score were 0.90 (0.68-1.18, p-value, test for trend = 0.54) for the prudent dietary pattern and 0.97 (0.71-1.33, p-value, test for trend = 0.97) for the Western dietary pattern. CONCLUSIONS: Our findings suggest that there is no overall association between dietary patterns and risk of breast cancer. However, we found an inverse association between the prudent dietary pattern and breast cancer risk among ever smokers, but the test for interaction was not significant. We suggest that this finding merits further evaluation. © 2005 Elsevier Inc. All rights reserved.

Author Keywords

Breast cancer dietary pattern

Index Keywords

breast cancer follow up human risk assessment middle aged controlled study priority journal diet cancer risk comparative study Confidence interval premenopause Humans Breast Neoplasms smoking female Risk Factors questionnaire Incidence scoring system Article major clinical study adult menopause dietary intake
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-27644480891&doi=10.1016%2fj.annepidem.2005.01.008&partnerID=40&md5=de0a898c4cc13463b27f6c6ef6ee89d9
DOI: 10.1016/j.annepidem.2005.01.008
ISSN: 10472797
Cited by: 68
Original Language: English