International Journal of Tuberculosis and Lung Disease
Volume 9, Issue 9, 2005, Pages 1018-1026
Population-based risk factors for tuberculosis and adverse outcomes among Tibetan refugees in India, 1994-1996 (Article)
Nelson L.J.* ,
Naik Y. ,
Tsering K. ,
Cegielski J.P.
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a
Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, GA, United States, Division of TB Elimination, Centers for Disease Control and Prevention, MS E-10, 1600 Clifton Road, Atlanta, GA 30333, United States
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b
Data Unit, Health Department, Tibetan Government in Exile, Dharamsala, Himachal Pradesh, India
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c
Tuberculosis Unit, Health Department, Tibetan Government in Exile, Dharamsala, Himachal Pradesh, India
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d
Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, GA, United States
Abstract
SETTING: Tibetan refugees in India, 1994-1996. OBJECTIVE: To determine tuberculosis (TB) incidence, independent risk factors for TB, and predictors of adverse outcomes. DESIGN: Data from a house-to-house census/demographic survey were merged with TB patient data. Separate multivariable models for each birthplace were developed for outcomes of interest. RESULTS: From 1994 to 1996, 47 491 Tibetans were surveyed and 1197 TB cases confirmed (incidence 835/ 100 000). Risk factors for TB in separate multivariable models differed by place of birth. Independent predictors of death for Tibet-born refugees included age ≥50 years, extra-pulmonary TB, and second-line therapy, while for India-born refugees they included second-line therapy and no improvement at the end of treatment. No significant risk factors for default were identified for Tibet-born refugees, while region of residence and the absence of a BCG scar were independent predictors among those born in India. Predictors of receipt of second-line therapy among Tibet-born refugees included region, years in camps, and prior TB, while among those born in India they were region, age ≥20 years, sputum-positive at diagnosis, and previous TB. CONCLUSIONS: TB incidence in Tibetan refugee settlements exceeds the highest national TB rates, and country of birth determines risk factors. TB control efforts in India should include this population. © 2005 The Union.
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-27644448759&partnerID=40&md5=119c865a167a799845bd56390269b13f
ISSN: 10273719
Cited by: 13
Original Language: English