International Journal of Tuberculosis and Lung Disease
Volume 9, Issue 9, 2005, Pages 1018-1026

Population-based risk factors for tuberculosis and adverse outcomes among Tibetan refugees in India, 1994-1996 (Article)

Nelson L.J.* , Naik Y. , Tsering K. , Cegielski J.P.
  • a Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, GA, United States, Division of TB Elimination, Centers for Disease Control and Prevention, MS E-10, 1600 Clifton Road, Atlanta, GA 30333, United States
  • b Data Unit, Health Department, Tibetan Government in Exile, Dharamsala, Himachal Pradesh, India
  • c Tuberculosis Unit, Health Department, Tibetan Government in Exile, Dharamsala, Himachal Pradesh, India
  • d Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, GA, United States

Abstract

SETTING: Tibetan refugees in India, 1994-1996. OBJECTIVE: To determine tuberculosis (TB) incidence, independent risk factors for TB, and predictors of adverse outcomes. DESIGN: Data from a house-to-house census/demographic survey were merged with TB patient data. Separate multivariable models for each birthplace were developed for outcomes of interest. RESULTS: From 1994 to 1996, 47 491 Tibetans were surveyed and 1197 TB cases confirmed (incidence 835/ 100 000). Risk factors for TB in separate multivariable models differed by place of birth. Independent predictors of death for Tibet-born refugees included age ≥50 years, extra-pulmonary TB, and second-line therapy, while for India-born refugees they included second-line therapy and no improvement at the end of treatment. No significant risk factors for default were identified for Tibet-born refugees, while region of residence and the absence of a BCG scar were independent predictors among those born in India. Predictors of receipt of second-line therapy among Tibet-born refugees included region, years in camps, and prior TB, while among those born in India they were region, age ≥20 years, sputum-positive at diagnosis, and previous TB. CONCLUSIONS: TB incidence in Tibetan refugee settlements exceeds the highest national TB rates, and country of birth determines risk factors. TB control efforts in India should include this population. © 2005 The Union.

Author Keywords

India Refugees Tibet tuberculosis

Index Keywords

China Tibet refugee sputum smear India human Refugees middle aged priority journal BCG vaccine population risk health program Humans tuberculostatic agent Adolescent male female tuberculosis risk factor outcomes research BCG vaccination Risk Factors Infant Multivariate Analysis Article major clinical study adult thorax radiography tuberculosis control Directly Observed Therapy Child

Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-27644448759&partnerID=40&md5=119c865a167a799845bd56390269b13f

ISSN: 10273719
Cited by: 13
Original Language: English