Journal of Urology
Volume 191, Issue 4, 2014, Pages 952-956

Prostate cancer risk profiles of Asian-American men: Disentangling the effects of immigration status and race/ethnicity (Article)

Lichtensztajn D.Y.* , Gomez S.L. , Sieh W. , Chung B.I. , Cheng I. , Brooks J.D.
  • a Cancer Prevention Institute of California, 2201 Walnut Ave., Fremont, CA 94538, United States
  • b Cancer Prevention Institute of California, 2201 Walnut Ave., Fremont, CA 94538, United States, Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, United States
  • c Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, United States
  • d Department of Urology, Stanford University School of Medicine, Stanford, CA, United States
  • e Cancer Prevention Institute of California, 2201 Walnut Ave., Fremont, CA 94538, United States
  • f Department of Urology, Stanford University School of Medicine, Stanford, CA, United States

Abstract

Purpose Asian-American men with prostate cancer have been reported to present with higher grade and later stage disease than white American men. However, Asian-American men comprise a heterogeneous population with distinct health outcomes. We compared prostate cancer risk profiles among the diverse racial and ethnic groups in California. Materials and Methods We used data from the California Cancer Registry on 90,845 nonHispanic white, nonHispanic black and Asian-American men diagnosed with prostate cancer between 2004 and 2010. Patients were categorized into low, intermediate and high risk groups based on clinical stage, Gleason score and prostate specific antigen at diagnosis. Using polytomous logistic regression we estimated adjusted ORs for the association of race/ethnicity and nativity with risk group. Results In addition to the nonHispanic black population, 6 Asian-American groups (United States born Chinese, foreign born Chinese, United States born Japanese, foreign born Japanese, foreign born Filipino and foreign born Vietnamese) were more likely to have an unfavorable risk profile compared to nonHispanic white men. The OR for high vs intermediate risk disease ranged from 1.23 (95% CI 1.02-1.49) for United States born Japanese men to 1.45 (95% CI 1.31-1.60) for foreign born Filipino men. These associations appeared to be driven by higher grade and prostate specific antigen rather than by advanced clinical stage at diagnosis. Conclusions In this large, ethnically diverse, population based cohort Asian-American men were more likely to have an unfavorable risk profile at diagnosis. This association varied by racial/ethnic group and nativity, and was not attributable to later stage at diagnosis. This suggests that Asian men may have biological differences that predispose to more severe disease. © 2014 by AMERICAN UROLOGICAL ASSOCIATION EDUCATION AND RESEARCH, INC.

Author Keywords

Prostatic neoplasms SEER program Asian Americans Epidemiology prostate

Index Keywords

Prostatic Neoplasms prostate race difference prostate cancer human risk assessment epidemiology priority journal cancer risk United States Humans California Asian Americans male Asian American high risk population cancer registry Article prostate specific antigen major clinical study Gleason score European Continental Ancestry Group cohort analysis Emigration and Immigration African Americans disease association SEER Program
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84898484836&doi=10.1016%2fj.juro.2013.10.075&partnerID=40&md5=fe0488644a2d4e033a416bd4e0b37bfa
DOI: 10.1016/j.juro.2013.10.075
ISSN: 00225347
Cited by: 21
Original Language: English