Journal of General Virology
Volume 93, Issue 3, 2012, Pages 541-550

Reintroduction of h5n1 highly pathogenic avian influenza virus by migratory water birds, causing poultry outbreaks in the 2010-2011 winter season in Japan (Article) (Open Access)

Sakoda Y. , Lto H. , Uchida Y. , Okamatsu M. , Yamamoto N. , Soda K. , Nomura N. , Kuribayashi S. , Shichinohe S. , Sunden Y. , Umemura T. , Usui T. , Ozaki H. , Yamaguchi T. , Murase T. , Ito T. , Saito T. , Takada A. , Kida H.*
  • a Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
  • b Laboratory of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan, Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan
  • c Research Team for Zoonotic Diseases, National Institute of Animal Health, Tsukuba 305-0856, Japan
  • d Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
  • e Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
  • f Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan, Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan
  • g Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
  • h Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
  • i Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
  • j Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
  • k Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
  • l Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan, Laboratory of Veterinary Hygiene, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan
  • m Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan, Laboratory of Veterinary Microbiology, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan
  • n Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan, Laboratory of Veterinary Hygiene, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan
  • o Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan, Laboratory of Veterinary Microbiology, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan
  • p Laboratory of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan, Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan
  • q Research Team for Zoonotic Diseases, National Institute of Animal Health, Tsukuba 305-0856, Japan
  • r Research Center for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan
  • s Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan, Research Center for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan, Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi 332-0012, Japan

Abstract

H5N1 highly pathogenic avian influenza virus (HPAIV) was reintroduced and caused outbreaks in chickens in the 2010-2011 winter season in Japan, which had been free from highly pathogenic avian influenza (HPAI) since 2007 when HPAI outbreaks occurred and were controlled. On 14 October 2010 at Lake Ohnuma, Wakkanai, the northernmost part of Hokkaido, Japan, H5N1 HPAIVs were isolated from faecal samples of ducks flying from their nesting lakes in Siberia. Since then, in Japan, H5N1 HPAIVs have been isolated from 63 wild birds in 17 prefectures and caused HPAI outbreaks in 24 chicken farms in nine prefectures by the end of March in 2011. Each of these isolates was genetically closely related to the HPAIV isolates at Lake Ohnuma, and those in China, Mongolia, Russia and Korea, belonging to genetic clade 2.3.2.1. In addition, these isolates were genetically classified into three groups, suggesting that the viruses were transmitted by migratory water birds through at least three different routes from their northern territory to Japan. These isolates were antigenic variants, which is consistent with selection in poultry under the immunological pressure induced by vaccination. To prevent the perpetuation of viruses in the lakes where water birds nest in summer in Siberia, prompt eradication of HPAIVs in poultry is urgently needed in Asian countries where HPAI has not been controlled. © 2012 SGM.

Author Keywords

[No Keywords available]

Index Keywords

genotype China Gallus gallus molecular epidemiology Sequence Analysis, DNA Aves Molecular Sequence Data controlled study priority journal Animals virus identification nonhuman RNA, Viral virus isolation cluster analysis Influenza Vaccines duck classification chicken Japan Mongolia migratory species Disease Outbreaks Article epidemic Anas Phylogeny winter Feces genetic variation antigenic variation Selection, Genetic water bird H5N1 highly pathogenic avian influenza virus bird disease Chickens Birds Avian influenza virus Ducks Influenza in Birds Influenza virus A H5N1 vaccination Influenza A Virus, H5N1 Subtype Poultry Diseases Russian Federation Korea
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84857099618&doi=10.1099%2fvir.0.037572-0&partnerID=40&md5=71357668fedaf7985a12a867431d5414
DOI: 10.1099/vir.0.037572-0
ISSN: 00221317
Cited by: 68
Original Language: English