Cancer
Volume 116, Issue 11, 2010, Pages 2531-2542

Cervical cancer prevention: New tools and old barriers (Review)

Scarinci I.C. , Garcia F.A.R. , Kobetz E. , Partridge E.E. , Brandt H.M. , Bell M.C. , Dignan M. , Ma G.X. , Daye J.L. , Castle P.E.
  • a Division of Preventive Medicine, University of Alabama at Birmingham, 1530 Third Avenue South MT 609, Birmingham, AL 35294-4410, United States, University of Alabama at Birmingham Comprehensive Cancer, University of Alabama at Birmingham, Birmingham, AL, United States
  • b Department of Obstetrics and Gynecology, University of Arizona, Tucson, AZ, United States
  • c Department of Epidemiology and Public Health, University of Miami, Miller School of Medicine, Miami, FL, United States
  • d University of Alabama at Birmingham Comprehensive Cancer, University of Alabama at Birmingham, Birmingham, AL, United States
  • e Department of Health Promotion, Education, and Behavior, University of South Carolina, Columbia, SC, United States
  • f Sanford Women's Health, Sanford Clinic, Sioux Falls, SD, United States
  • g Prevention Research Center, University of Kentucky, Lexington, KY, United States
  • h Center for Asian Health, Temple University, Philadelphia, PA, United States
  • i Center for Reducing Cancer Health Disparities, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States
  • j Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States

Abstract

Cervical cancer is the second most common female tumor worldwide, and its incidence is disproportionately high (>80%) in the developing world. In the United States, in which Papanicolaou (Pap) tests have reduced the annual incidence to approximately 11,000 cervical cancers, >60% of cases are reported to occur in medically underserved populations as part of a complex of diseases linked to poverty, race/ethnicity, and/or health disparities. Because carcinogenic human papillomavirus (HPV) infections cause virtually all cervical cancer, 2 new approaches for cervical cancer prevention have emerged: 1) HPV vaccination to prevent infections in younger women (aged ≤18 years) and 2) carcinogenic HPV detection in older women (aged ≥30 years). Together, HPV vaccination and testing, if used in an age-appropriate manner, have the potential to transform cervical cancer prevention, particularly among underserved populations. Nevertheless, significant barriers of access, acceptability, and adoption to any cervical cancer prevention strategy remain. Without understanding and addressing these obstacles, these promising new tools for cervical cancer prevention may be futile. In the current study, the delivery of cervical cancer prevention strategies to these US populations that experience a high cervical cancer burden (African-American women in South Carolina, Alabama, and Mississippi; Haitian immigrant women in Miami; Hispanic women in the US-Mexico Border; Sioux/Native American women in the Northern Plains; white women in the Appalachia; and Vietnamese-American women in Pennsylvania and New Jersey) is reviewed. The goal was to inform future research and outreach efforts to reduce the burden of cervical cancer in underserved populations. © 2010 American Cancer Society.

Author Keywords

Cervical cancer Human papillomavirus vaccination Cervical cancer prevention Human papillomavirus testing

Index Keywords

Vaginal Smears Vietnam Indians, North American immigrant human priority journal cancer prevention Early Detection of Cancer African American groups by age Hispanic Americans screening Wart virus Haiti United States health program Humans virus detection Hispanic Papillomavirus Vaccines Wart virus vaccine Asian American female Review high risk population uterine cervix cancer health care access Uterine Cervical Neoplasms Papanicolaou Test vaccination Healthcare Disparities personal hygiene virus carcinogenesis African Americans cancer incidence condyloma acuminatum
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-77952837934&doi=10.1002%2fcncr.25065&partnerID=40&md5=3857bc724591f38b8e715700946935fc
DOI: 10.1002/cncr.25065
ISSN: 0008543X
Cited by: 180
Original Language: English