European Respiratory Journal
Volume 35, Issue 6, 2010, Pages 1346-1353

Predictive value for progression to tuberculosis by IGRA and TST in immigrant contacts (Article) (Open Access)

Kik S.V. , Franken W.P.J. , Mensen M. , Cobelens F.G.J. , Kamphorst M. , Arend S.M. , Erkens C. , Gebhard A. , Borgdorff M.W. , Verver S.
  • a KNCV Tuberculosis Foundation, PO Box 146, 2501 CC The Hague, Netherlands, Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, Netherlands
  • b Dept of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands
  • c Dept. of Tuberculosis Control, Municipal Health Service, Amsterdam, Netherlands
  • d KNCV Tuberculosis Foundation, PO Box 146, 2501 CC The Hague, Netherlands, Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, Netherlands
  • e Dept. of Tuberculosis Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, Netherlands
  • f Dept of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands
  • g KNCV Tuberculosis Foundation, PO Box 146, 2501 CC The Hague, Netherlands
  • h KNCV Tuberculosis Foundation, PO Box 146, 2501 CC The Hague, Netherlands, Dept. of Tuberculosis Control, Municipal Health Service West-Brabant, Breda, Netherlands
  • i KNCV Tuberculosis Foundation, PO Box 146, 2501 CC The Hague, Netherlands, Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, Netherlands
  • j KNCV Tuberculosis Foundation, PO Box 146, 2501 CC The Hague, Netherlands, Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, Netherlands

Abstract

The authors determined the positive predictive value (PPV) for progression to tuberculosis (TB) of two interferon-γ release assays (IGRAs), QuantiFERON-TB® Gold In-tube (QFT-GIT) and T-SPOT.TB®, and the tuberculin skin test (TST) in immigrants contacts. Immigrant close contacts of sputum smear-positive TB patients were included when aged ≥16 yrs and their TST result was ≥5 mm 0 or 3 months after diagnosis of the index patient. Contacts were followed for the next 2 yrs for development of TB disease. Of 339 immigrant contacts with TST ≥5 mm, 324 and 299 had valid results of QFT-GIT and T-SPOT.TB®, respectively. Nine contacts developed active TB. One patient had not been tested with TST, while another patient had not been tested with QFT-GIT and T-SPOT.TB®. The PPV for progression to TB during this period was 9/288=3.1% (95% CI 1.3-5.0%) for TST ≥10 mm, 7/184=3.8% (95% CI 1.7-5.9%) for TST o15 mm, 5/178=2.8% (95% CI 1.0-4.6%) for QFT-GIT and 6/181=3.3% (95% CI 1.3-5.3%) for T-SPOT.TB®. Sensitivity was 100%, 88%, 63% and 75%, respectively. The predictive values of QFT-GIT, T-SPOT.TB1 and TST for progression to TB disease among immigrant close contacts were comparable. Copyright©ERS 2010.

Author Keywords

immigrants Interferon-γ release assay Contact tracing Predictive value tuberculosis Tuberculin skin test

Index Keywords

Netherlands immigrant sputum smear protein determination reinfection Follow-Up Studies follow up Prospective Studies human diagnostic accuracy controlled study priority journal comparative study BCG vaccine disease course Young Adult Humans lung tuberculosis diagnostic value Adolescent male Emigrants and Immigrants Tuberculosis, Pulmonary female prediction Risk Factors gamma interferon Incidence Contact Tracing Article major clinical study tuberculin test adult infection risk Predictive Value of Tests Interferon-gamma Reagent Kits, Diagnostic Enzyme-Linked Immunosorbent Assay
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-77953519650&doi=10.1183%2f09031936.00098509&partnerID=40&md5=22f1521be4591a45bc7c479c17eb40bd
DOI: 10.1183/09031936.00098509
ISSN: 09031936
Cited by: 109
Original Language: English