Epidemiology and Infection
Volume 139, Issue 4, 2011, Pages 572-580

Marching cohort of Helicobacter pylori infection over two decades (1988-2007): Combined effects of secular trend and population migration (Article)

Miendje Deyi V.Y.* , Vanderpas J. , Bontems P. , Van Den Borre C. , De Koster E. , Cadranel S. , Burette A.
  • a Clinical Biology Department, Université Libre de Bruxelles, Brugmann University Hospital, Brussels, Belgium
  • b Epidemiology and Infection Control Unit, Brugmann University Hospital, Université Libre de Bruxelles, Brussels, Belgium, Medical Microbiology Laboratory, Scientific Institute of Public Health, Brussels, Belgium
  • c Gastroenterology Department, Queen Fabiola Children's University Hospital, Université Libre de Bruxelles, Brussels, Belgium
  • d Clinical Biology Department, Université Libre de Bruxelles, Brugmann University Hospital, Brussels, Belgium
  • e Gastroenterology Department, Brugmann University Hospital, Université Libre de Bruxelles, Brussels, Belgium
  • f Gastroenterology Department, Queen Fabiola Children's University Hospital, Université Libre de Bruxelles, Brussels, Belgium
  • g Gastroenterology Department, Centre Hospitalier Interrégional Edith Cavell, Sites de la Basilique et E. Cavell, Brussels, Belgium

Abstract

The prevalence of Helicobacter pylori infection is decreasing in developed countries. In this study we included 22 612 patients in whom a first culture of gastric biopsy (routinely performed in our medical centres) yielded an interpretable result over a 20-year period (1988-2007) in Brussels. The effects of patients' age, gender and ethnic background were analysed. The overall proportion of H. pylori-infected patients was 37·7%, with a progressive decline over time (P<10 -5). A gender effect was observed in adults. The lowest infection rate was observed in Western European patients (n=11 238) with respectively 36·2% and 15·2% infected subjects in 1988 and 2007, compared to 71·7% and 40% in North African patients (n=3200) (P<10 -5). However, no trend of decline was observed over time in North African children aged ≤9 years. These data show the effects of time, age and ethnicity on the prevalence of H. pylori infection, and its complex heterogeneity in the same cosmopolitan urban area. © Copyright Cambridge University Press 2010.

Author Keywords

dynamic of infection Helicobacter pylori Epidemiology ethnic background

Index Keywords

urban area stomach mucosa human infection rate trend study middle aged sex difference Cohort Studies Ethnic Groups Gastric Mucosa ethnic group controlled study illness trajectory Aged biopsy Young Adult Humans ethnic difference Adolescent stomach biopsy Infant, Newborn male preschool child Aged, 80 and over Infant risk factor Helicobacter infection Risk Factors Child, Preschool newborn female Belgium prevalence isolation and purification Article disease transmission major clinical study adult Helicobacter Infections migration Helicobacter pylori age Age Factors microbiology cohort analysis Emigration and Immigration disease association population migration Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-79955682660&doi=10.1017%2fS095026881000110X&partnerID=40&md5=3979ff7c5796e288705e3fbda3fd6aac
DOI: 10.1017/S095026881000110X
ISSN: 09502688
Cited by: 25
Original Language: English