Acta Paediatrica, International Journal of Paediatrics
Volume 100, Issue 4, 2011, Pages 578-584

Ethnicity and comorbidities in an overweight and obese multiethnic childhood cohort in Berlin (Article)

Dannemann A. , Ernert A. , Rücker P. , Bau A.M. , Martus P. , Krude H. , Babitsch B. , Wiegand S.*
  • a Department of Pediatric Endocrinology and Diabetology, Charité Children's Hospital, Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
  • b Department of Epidemiology, Charité - Universitätsmedizin Berlin, Berlin, Germany
  • c Department of Pediatric Endocrinology and Diabetology, Charité Children's Hospital, Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
  • d Department of Pediatric Endocrinology and Diabetology, Charité Children's Hospital, Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
  • e Department of Epidemiology, Charité - Universitätsmedizin Berlin, Berlin, Germany
  • f Department of Pediatric Endocrinology and Diabetology, Charité Children's Hospital, Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
  • g Berlin School of Public Health, Charité - Universitätsmedizin Berlin, Berlin, Germany
  • h Department of Pediatric Endocrinology and Diabetology, Charité Children's Hospital, Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany

Abstract

Aim: This study aims to analyse the association between ethnicity, elevated metabolic parameters and metabolic syndrome (MS) in a multiethnic cohort of overweight to obese children and adolescents. Methods: For 1053 patients, standard deviation of body mass index (BMI-SDS) was calculated and metabolic parameters (fasting blood glucose, fasting insulin, homeostasis model assessment-IR, lipids, blood pressure) were measured. MS was defined by WHO criteria. Bivariate and multivariate analyses were performed. Adjusted differences in BMI-SDS and metabolic parameters between different migration groups were assessed with linear regression models. The risk for MS was calculated with multiple logistic regression models. Results: Forty-eight per cent of the children were German, 25% Turkish and 27% had another ethnicity. Concerning weight status, 23% are overweight, 31% obese and 46% extremely obese with higher rates among the immigrant population. Multivariable models indicate significant associations between elevated metabolic parameters and higher BMI-SDS values. Overall prevalence of MS was 32.3%. MS was detected significantly more often among Turkish patients (40.4%) compared to Germans (27.3%; p = 0.02). Logistic regression analysis showed a greater risk for MS with older age (OR = 1.09; p = 0.003) and Turkish ethnicity (OR = 1.62; p = 0.02). Conclusion: Nearly all patients had symptoms of MS, and 40% had MS showing that this highly health-threatening condition is quite common. Therefore, effective therapy and prevention efforts must be developed for this high risk group. More migration-specific research regarding insulin resistance, MS and Type 2 DM is needed. ©2011 The Author(s)/Acta Pædiatrica ©2011 Foundation Acta Pædiatrica.

Author Keywords

Childhood obesity Ethnicity Care level Metabolic syndrome

Index Keywords

Germany immigrant insulin resistance metabolic syndrome X low density lipoprotein cholesterol human risk assessment comorbidity Cohort Studies metabolic parameters Overweight Ethnic Groups controlled study Turkey (republic) priority journal obesity diet restriction lipid lipid blood level insulin school child Humans ethnic difference Adolescent male Emigrants and Immigrants female Risk Factors homeostasis prevalence cholesterol Article glucose blood level major clinical study age body weight Turkey high density lipoprotein cholesterol insulin blood level triacylglycerol age distribution blood pressure measurement glucose body mass disease association Body Mass Index Berlin Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-79952760171&doi=10.1111%2fj.1651-2227.2010.02119.x&partnerID=40&md5=d170847b0c3ee8689c31641fec76d2e7
DOI: 10.1111/j.1651-2227.2010.02119.x
ISSN: 08035253
Cited by: 6
Original Language: English