Internal and Emergency Medicine
Volume 6, Issue 1, 2011, Pages 35-39

Helicobacter pylori eradication: Are we really all equal? A controlled study in native and immigrant population (Article)

Gatta L.* , Di Mario F. , Vaira D. , Franzé A. , Rugge M. , Pilotto A. , Lucarini P. , Lera M. , Fiorini G. , Castelli V. , Kajo E. , Scarpignato C.
  • a Gastroenterology and Endoscopy Unit, Versilia Hospital, Lido di Camaiore, Italy, Section of Gastroenterology, Department of Clinical Science, University of Parma, Via Gramsci 14, 43100 Parma, Italy
  • b Section of Gastroenterology, Department of Clinical Science, University of Parma, Via Gramsci 14, 43100 Parma, Italy
  • c Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
  • d Gastroenterology Unit, Hospital of Parma, Parma, Italy
  • e Department of Medical Diagnostic Sciences and Special Therapies (Pathology Unit), University of Padova, Padua, Italy
  • f Geriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
  • g Gastroenterology and Endoscopy Unit, Versilia Hospital, Lido di Camaiore, Italy
  • h Gastroenterology and Endoscopy Unit, Versilia Hospital, Lido di Camaiore, Italy
  • i Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
  • j Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
  • k Department of Internal Medicine, Aging and Kidney Disease, Alma Mater Studiorum, University of Bologna, Bologna, Italy
  • l Section of Gastroenterology, Department of Clinical Science, University of Parma, Via Gramsci 14, 43100 Parma, Italy

Abstract

Italy's shift to a tertiary economy has modified the working market, concentrating demand also on unqualified one, which includes most immigrants. It is also well established that low socio-economical conditions are associated with an increased prevalence of H. pylori infection. The aims of this study were to compare: (1) the efficacy of a 7 days triple therapy in immigrant and in Italian patients; (2) the prevalence of PUD between these two groups of patients. A total of 116 consecutive immigrant and 112 Italian H. pylori infected patients were recruited between 2007 and 2008. Patients underwent 13C-UBT, endoscopy with biopsies, and were offered a 7-day triple therapy. Eradication rate (ER) was assessed 8 weeks after the end of the treatment using 13C-UBT. The two populations differed for median age (p < 0.01), prevalence of PUD (p < 0.01), and smoking status (p < 0.01). The ER according to the ITT analysis was 70% for Italian and 48.3% for immigrant (p < 0.01). Multivariate analysis including country of origin, sex, age, PUD, smoking, and alcohol status found that immigrant had an adjusted OR for not eradicating of 2.14 (p = 0.03). In immigrant patients resident in Italy, performance of triple therapy was lower than expected. Further studies are demanded to confirm and clarify these intriguing results. © 2010 SIMI.

Author Keywords

Eradication therapy Immigrant population Helicobacter pylori

Index Keywords

[No Keywords available]
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85027934900&doi=10.1007%2fs11739-010-0443-0&partnerID=40&md5=3152f27473c687caf5add463d530fb41
DOI: 10.1007/s11739-010-0443-0
ISSN: 18280447
Cited by: 7
Original Language: English