Aims: Non-alcohol fatty liver disease (NAFLD) is a strong risk factor for insulin resistance and type 2 diabetes. The prevalence of NAFLD varies across populations of different ethnic backgrounds but the prevalence in Middle Eastern populations, which are at high risk of type 2 diabetes, is largely unknown. Using fatty liver index (FLI) as a proxy for NAFLD the aim was to calculate the odds of NAFLD (FLI ≥ 70) given country of origin and further to investigate the associations between ISI and FLI. Methods: In 2010-2012 we conducted a population-based study of individuals aged 30-75 years born in Iraq or Sweden, in whom anthropometrics, fasting blood samples and oral glucose tolerance tests were performed and sociodemography and lifestyle behaviors characterized. Results: A higher proportion of Iraqis (N = 1085) than Swedes (N = 605) had a high probability of NAFLD (FLI≥70, 32.5 vs. 22.6%, p<0.001, age- and sex-adjusted data) and ISI was more severely impaired (70.7 vs. 95.9%, p<0.001). Independently of traditional risk factors for NAFLD, being born in Iraqi increased the risk of FLI ≥ 70 (OR 1.59: 95% CI 1.15, 2.20). Furthermore, country of birth presented a stronger association between ISI and FLI ≥ 70 in Iraqis than in Swedes (Pinteraction = 0.019). Conclusions: Our data indicate that immigrants from Iraq are at higher risk of NAFLD. The finding that country of birth modifies the relationship of FLI with ISI, suggests that liver fat may be a stronger determinant of impaired insulin action and increased risk of type 2 diabetes in Iraqis than in Swedes. © 2015 The Authors.

Non-alcohol fatty liver disease type 2 diabetes insulin sensitivity Middle East

blood sampling immigrant lifestyle insulin resistance Iraqi metabolism demography non insulin dependent diabetes mellitus complication Continental Population Groups human ancestry group epidemiology middle aged birthplace Middle East Diabetes Mellitus, Type 2 statistics and numerical data controlled study risk assessment Iraq probability Aged diet restriction ethnology Residence Characteristics Cross-Sectional Studies insulin Sweden cross-sectional study migrant ethnic difference Swede (people) Humans male Emigrants and Immigrants hormone action female risk factor Risk Factors population research prevalence Glucose Tolerance Test oral glucose tolerance test Article major clinical study adult age cohort analysis fatty liver index disease severity digestive tract parameters nonalcoholic fatty liver anthropometry Non-alcoholic Fatty Liver Disease insulin sensitivity index disease association high risk patient sex social behavior