A scoping review of cost-effectiveness of screening and treatment for latent tuberculosis infection in migrants from high-incidence countries

BMC Health Services Research
Volume 15, Issue 1, 2015

A scoping review of cost-effectiveness of screening and treatment for latent tuberculosis infection in migrants from high-incidence countries (Review) (Open Access)

Zammarchi L. , Casadei G. , Strohmeyer M. , Bartalesi F. , Liendo C. , Matteelli A. , Bonati M. , Gotuzzo E. , Bartoloni A.* , Pandolfini C. , Severino F. , Confalonieri V. , Tognoni G. , Bisoffi Z. , Buonfrate D. , Angheben A. , Albonico M. , Muñoz J. , Requena-Mendez A. , Roura M. , Ventura L. , Pool R. , Pell C. , Hardon A. , Chiodini P. , Moreira J. , Anselmi M. , Sempértegui R. , Mena M.A. , Garcia H.H. , Bustos J. , Santivañez S. , Torrico F. , Lozano D. , Cabrera T.H. , Morón J.O. , AbaporiCuellar I. , Suarez J.A. , ChumirayRojas G. , Nicoletti A. , Bruno E. , COHEMI Project Study Group

^a Diseases Unit, Department of Experimental and Clinical Medicine, University of Florence School of Medicine, Largo Brambilla 3, Florence, 50134, Italy
^b Laboratory for Mother and Child Health, Department of Public Health, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Via G. La Masa 19, Milan, 20156, Italy
^c Diseases Unit, Department of Experimental and Clinical Medicine, University of Florence School of Medicine, Largo Brambilla 3, Florence, 50134, Italy
^d SOD Malattie Infettive e Tropicali, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, Florence, 50134, Italy
^e Instituto de Medicina Tropical 'Alexander von Humboldt', Universidad Peruana Cayetano Heredia, Barrios Altos, Lima, Peru
^f Institute of Infectious and Tropical Diaseases, WHO Collaborting Centre for TB Co-infection and TB Elimination, University of Brescia, Brescia, Italy
^g Laboratory for Mother and Child Health, Department of Public Health, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Via G. La Masa 19, Milan, 20156, Italy
^h Instituto de Medicina Tropical 'Alexander von Humboldt', Universidad Peruana Cayetano Heredia, Barrios Altos, Lima, Peru
ⁱ Diseases Unit, Department of Experimental and Clinical Medicine, University of Florence School of Medicine, Largo Brambilla 3, Florence, 50134, Italy, SOD Malattie Infettive e Tropicali, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, Florence, 50134, Italy
^j Laboratory for Mother and Child Health, Department of Public Health, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Via G. La Masa 19, Milan, 20156, Italy
^k Laboratory for Mother and Child Health, Department of Public Health, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Via G. La Masa 19, Milan, 20156, Italy
^l Laboratory for Mother and Child Health, Department of Public Health, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Via G. La Masa 19, Milan, 20156, Italy
^m Laboratory for Mother and Child Health, Department of Public Health, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Via G. La Masa 19, Milan, 20156, Italy
ⁿ Centre for Tropical Diseases, SacroCuore-Don Calabria Hospital, Negrar, Verona, Italy
^o Centre for Tropical Diseases, SacroCuore-Don Calabria Hospital, Negrar, Verona, Italy
^p Centre for Tropical Diseases, SacroCuore-Don Calabria Hospital, Negrar, Verona, Italy
^q Centre for Tropical Diseases, SacroCuore-Don Calabria Hospital, Negrar, Verona, Italy, Ivo de Carneri Foundation, Milano, Italy
^r Servicio de Medicina Tropical y SaludInternacional, Centre de Recerca en SalutInternacional de Barcelona, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain
^s Servicio de Medicina Tropical y SaludInternacional, Centre de Recerca en SalutInternacional de Barcelona, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain
^t Servicio de Medicina Tropical y SaludInternacional, Centre de Recerca en SalutInternacional de Barcelona, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain
^u Servicio de Medicina Tropical y SaludInternacional, Centre de Recerca en SalutInternacional de Barcelona, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain
^v Centre for Social Science and Global Health, University of Amsterdam, Netherlands
^w Centre for Social Science and Global Health, University of Amsterdam, Netherlands
^x Centre for Social Science and Global Health, University of Amsterdam, Netherlands
^y Hospital for Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
^z Centre for Community Epidemiology and Tropical Medicine, Esmeraldas, Ecuador
^a Centre for Community Epidemiology and Tropical Medicine, Esmeraldas, Ecuador
^b Centre for Community Epidemiology and Tropical Medicine, Esmeraldas, Ecuador
^c Instituto de Medicina Tropical 'Alexander von Humboldt', Universidad Peruana Cayetano Heredia, Barrios Altos, Lima, Peru
^d Cysticercosis Unit, Instituto de Ciencias Neurologicas, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru
^e Cysticercosis Unit, Instituto de Ciencias Neurologicas, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru
^f Cysticercosis Unit, Instituto de Ciencias Neurologicas, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru
^g Colectivo de EstudiosAplicados y Desarrollo Social, Cochabamba, Bolivia
^h Colectivo de EstudiosAplicados y Desarrollo Social, Cochabamba, Bolivia
ⁱ Taller de Educacion y Comunicacion TEKO-GUARANÌ, Camiri, Bolivia
^j Taller de Educacion y Comunicacion TEKO-GUARANÌ, Camiri, Bolivia
^k Taller de Educacion y Comunicacion TEKO-GUARANÌ, Camiri, Bolivia
^l Taller de Educacion y Comunicacion TEKO-GUARANÌ, Camiri, Bolivia
^m Taller de Educacion y Comunicacion TEKO-GUARANÌ, Camiri, Bolivia
ⁿ Dipartimento G.F. Ingrassia, Sezione di Neuroscienze, Università di Catania, Catania, Italy
^o Dipartimento G.F. Ingrassia, Sezione di Neuroscienze, Università di Catania, Catania, Italy
^p [Affiliation not available]

Abstract

Background: In low-incidence countries, most tuberculosis (TB) cases occur among migrants and are caused by reactivation of latent tuberculosis infection (LTBI) acquired in the country of origin. Diagnosis and treatment of LTBI are rarely implemented to reduce the burden of TB in immigrants, partly because the cost-effectiveness profile of this intervention is uncertain. The objective of this research is to perform a review of the literature to assess the cost-effectiveness of LTBI diagnosis and treatment strategies in migrants. Methods: Scoping review of economic evaluations on LTBI screening strategies for migrants was carried out in Medline. Results: Nine studies met the inclusion criteria. LTBI screening was cost-effective according to seven studies. Findings of four studies support interferon gamma release assay as the most cost-effective test for LTBI screening in migrants. Two studies found that LTBI screening is cost-effective only if carried out in immigrants who are contacts of active TB cases. Discussion and Conclusions: Our findings support the cost-effectiveness of LTBI diagnostic and treatment strategies in migrants especially if they are focused on young subjects from high incidence countries. These strategies could represent and adjunctive and synergistic tool to achieve the ambitious aim of TB elimination. © 2015 Zammarchi et al.

Author Keywords

[No Keywords available]

Index Keywords

Cost benefit analysis mass screening economics human Communicable Diseases interferon gamma release assay Interferon-gamma Release Tests dental procedure Dental Care Humans male latent tuberculosis female tuberculosis Incidence communicable disease tuberculin test migration Transients and Migrants cost-benefit analysis

Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84942156014&doi=10.1186%2fs12913-015-1045-3&partnerID=40&md5=516e6bdbe727edcea7f12ffe813cac3f

DOI: 10.1186/s12913-015-1045-3

ISSN: 14726963

Cited by: 36

Original Language: English