Tropical Medicine and Parasitology
Volume 39, Issue 1, 1988, Pages 40-42

Malaria prophylaxis with proguanil to Namibian refugee children in Angola (Article)

Saarinen M. , Thoren E. , Iyambo N. , Carlstedt A. , Shinyafa L. , Fernanda M. , Paajanen H. , Paajanen K. , Indongo I. , Rombo L.
  • a SWAPO Department of Health and Social Welfare, Luanda, Angola
  • b SWAPO Department of Health and Social Welfare, Luanda, Angola
  • c SWAPO Department of Health and Social Welfare, Luanda, Angola
  • d SWAPO Department of Health and Social Welfare, Luanda, Angola
  • e SWAPO Department of Health and Social Welfare, Luanda, Angola
  • f SWAPO Department of Health and Social Welfare, Luanda, Angola
  • g SWAPO Department of Health and Social Welfare, Luanda, Angola
  • h SWAPO Department of Health and Social Welfare, Luanda, Angola
  • i SWAPO Department of Health and Social Welfare, Luanda, Angola
  • j SWAPO Department of Health and Social Welfare, Luanda, Angola

Abstract

Following a presumptive treatment with 35 mg chloroquine base/kg, 484 Namibian children between 5 months and 5 years of age received 50 mg of proguanil daily for 4 months. They were compared with 268 children living in a very adjacent area who received vitamin tablets after the initial chloroquine medication. Fewer fever episodes were recorded among the children who received proguanil and they were also requiring less presumptive treatments with chloroquine during the period of study, but there were only minor differences in parasite rate between the two groups at the end of the study period. Despite the reduction of morbidity, the required efforts were too large to justify another period of drug prophylaxis.

Author Keywords

[No Keywords available]

Index Keywords

protozoon human epidemiology Refugees Angola controlled study Malaria comparative study Chloroguanide malaria control morbidity proguanil Namibia preschool child Infant Child, Preschool prevention drug therapy major clinical study human experiment age ethnic or racial aspects mortality chloroquine
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023927360&partnerID=40&md5=7950af743fbea914f0a296b023018268
ISSN: 01772392
Cited by: 4
Original Language: English