American Journal of Epidemiology
Volume 125, Issue 3, 1987, Pages 462-472

Inbreeding and prereproductive mortality in the old order amish. II. Genealogic epidemiology of prereproductive mortality (Article)

Khoury M.J. , Cohen B.H.* , Newill C.A. , Bias W. , Mckusick V.A.
  • a Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, 615 N. Wolfe St., Baltimore, MD 21205, United States
  • b Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, 615 N. Wolfe St., Baltimore, MD 21205, United States
  • c Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, 615 N. Wolfe St., Baltimore, MD 21205, United States
  • d [Affiliation not available]
  • e Deparment of Medicine, Johns Hopkins Hospital, Baltimore, MD, United States

Abstract

The effects of offspring and parental inbreeding on prereproductive mortality (death before age 20 years) in the historical population of the Lancaster County, Pennsylvania, Old Order Amish were investigated using the Amlsh genealogic registry, which contains Information on 42,465 births dating to the time of the pioneer migrants in the 1700s. Inbreeding coefficients for offspring and parents were computed using the path method of tracing common ancestors in the multigenerational pedigrees. In this population, prereproductlve mortality decfined from about 15% in the late 1800s to about 5% after 1930. Offspring inbreeding was found to be an independent predictor of prereproductive mortality after multivarlate adjustment for demographic risk factors for mortality. Moreover, the higher the coefficient, the higher the relative risk of prereproductive death, and the higher the risk of multiple deaths in the same sibship. There was no evidence of declining inbreeding effects over 10 generations of continuous inbreeding, nor of any significant parental inbreeding effects. Because of the high levels of inbreeding, it could be shown that inbreeding accounts for about 40% of all prereproductivo deaths in the present population. Genetic load analysis showed an average of about 1.7 lethal equivalents and a mostly mutational load. © 1987 by 1987 The Johns Hopkins University School of Hygiene and Public Health.

Author Keywords

Genealogy consanguinity Ethnic groups Religion Mortality inbreeding

Index Keywords

Parents risk human epidemiology middle aged priority journal Time Factors geographic distribution Aged genealogy Epidemiologic Methods ethnology Pennsylvania religion marriage Humans male consanguinity female adult heredity inbreeding ethnic or racial aspects mortality
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023099378&doi=10.1093%2foxfordjournals.aje.a114552&partnerID=40&md5=4042ec72f1b4ebecdc2e48d2861c03b9
DOI: 10.1093/oxfordjournals.aje.a114552
ISSN: 00029262
Cited by: 16
Original Language: English