It is shown that specificity of the genetic structure in individuals with different pathologic processes is interrelated to the duration of life under the extreme conditions, and its "dynamics" is contrary to that of healthy inhabitants of the region. The extent of genetic differences between groups in man and woman samples, and also between men and women in groups does not depend on the extent of differences between these groups in frequency of nosologic forms. The latter indicate that the genotype shows nonspecific disease resistance on the whole, but not to the given pathologic process. The prevalence of the average real heterozygosity over the theoretical one in sick men and the reverse effect in healthy men points to formation of new heterozygosity optimum in the extreme conditions, leading to decline in the population genetic diversity, which rather corresponds to the specific ecology. The comparison of groups of sick and healthy individuals of different life duration in the North shows that the specific weight of genotype nonspecific resistance to diseases depends mostly on the duration of life of individuals under extreme conditions, this dependence being not linear.

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medical genetics Genetics, Medical adaptation Disease Susceptibility human Time Factors Siberia chronic disease male female heterozygote Article Adaptation, Physiological adult English Abstract migration disease predisposition Emigration and Immigration genetic polymorphism Russian Federation Middle Age time Polymorphism (Genetics)