American Journal of Hematology
Volume 19, Issue 1, 1985, Pages 27-36

Hematologic genetic disorders among Southeast Asian refugees (Article)

Monzon C.M.* , Fairbanks V.F. , Burgert E.O., Jr. , Sutherland J.E., Jr. , Elliot S.C.
  • a Department of Child Health, University of Missouri Health Sciences Center, Columbia, United States
  • b Departments of Laboratory Medicine and Internal Medicine, Division of Hematology, Rochester, Minnesota, United States
  • c Department of Pediatrics, Mayo Medical School, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, United States
  • d Department of Family and Community Medicine, Univeristy of Minnesota, Minneapolis, Minnesota, United States
  • e Department of Pediatrics, Raymond Blank Memorial Hospital for Children, Des Moines, Iowa, United States

Abstract

Resettlement of Southeast Asian refugees has introduced into the Western Hemisphere many persons of all major ethnic groups from Indochina. They represent several distinctive cultural, genetic, and linguistic groups, and the prevalence of genetic traits among them varies accordingly. We studied 778 Southeast Asian persons resettled in the upper Midwest who belonged to 182 unrelated families from the five major Southeast Asian ethnic groups. High prevalences of hemoglobin E, α‐ and β‐thalassemia disorders, and glucose‐6‐phosphate dehydrogenase deficiency were found. The prevalences of these four conditions in the refugees are among the highest known in the world. For these groups, iron deficiency is an uncommon cause of microcytosis; instead, the most frequent causes are hemoglobin E and α‐thalassemia‐1. Very serious thalassemic disorders occur with unusually high frequency in the refugees, especially in the Tai‐Dam. Copyright © 1985 Wiley‐Liss, Inc., A Wiley Company

Author Keywords

Hemoglobin E hemoglobin nopaphies glucose phosphate dehydrogenase deficiency thalassemia

Index Keywords

thalassemia human ethnic group priority journal hemoglobin e Glucosephosphate Dehydrogenase Deficiency geographic distribution Erythrocytes, Abnormal Hematologic Diseases United States Humans male female Gene Frequency major clinical study heredity Sex Factors beta thalassemia glucose 6 phosphate dehydrogenase deficiency Asia, Southeastern blood and hemopoietic system
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021988512&doi=10.1002%2fajh.2830190105&partnerID=40&md5=e3f386dd029bc4d27bf21da510e22144
DOI: 10.1002/ajh.2830190105
ISSN: 03618609
Cited by: 18
Original Language: English