Acta Haematologica Japonica
Volume 46, Issue 1, 1983, Pages 18-24

Hb E/β 0-thalassemia in a Loatian refugee (Article)

Ohba Y. , Hattori Y. , Nakashima M. , Komazawa M. , Yamamoto K. , Matsuoka M. , Yoshinaka H. , Miyaji T.
  • a Dep. Clin. Pathol., Yamaguchi Univ. Sch. Med., Ube, Japan
  • b Dep. Clin. Pathol., Yamaguchi Univ. Sch. Med., Ube, Japan
  • c Dep. Clin. Pathol., Yamaguchi Univ. Sch. Med., Ube, Japan
  • d [Affiliation not available]
  • e [Affiliation not available]
  • f [Affiliation not available]
  • g [Affiliation not available]
  • h [Affiliation not available]

Abstract

Hemoglobin analyses on a Laotian girl with a long history of hemolytic anemia and members of her family were reported. Her hemoglobin consisted of a variant co-migrating with Hb A 2 in electrophoresis at pH 8.6 which, together with Hb A 2, comprised 3/4 of the total hemoglobin and Hb F. The absence of normal Hb A was confirmed by urea polyacrylamide gel electrophoresis of the total globin. The variant hemoglobin was identified as Hb E by fingerprinting and amino acid analysis of a relevant tryptic peptide. The patient was a Hb E/β 0-thalassemia double heterozygote. Segregation of Hb E, β 0-thalassemia and possibly elliptocytosis in this family was suggested.

Author Keywords

[No Keywords available]

Index Keywords

beta thalassemia case report hemoglobin e thalassemia hemoglobinopathy female Hemoglobins, Abnormal Laos diagnosis human Humans blood and hemopoietic system Adolescent
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0020585903&partnerID=40&md5=fa2b53150bf41d4393c4a3f89d3a5148
ISSN: 00015806
Original Language: English