The Journal of Pediatrics
Volume 102, Issue 5, 1983, Pages 692-697

Anemia and hemoglobinopathies in Southeast Asian refugee children (Article)

Hurst D.* , Tittle B. , Kleman K.M. , Embury S.H. , Lubin B.H.
  • a Northern California Sickle Cell Center, Oakland, CA, United States, Bruce Lyon Memorial Research Laboratory, Oakland, CA, United States, Department of Hematology/Oncology, Children's Hospital Medical Center of Northern California, Oakland, CA, United States, Department of Outpatient Services, Children's Hospital Medical Center of Northern California, Oakland, CA, United States, Hematology Division, San Francisco General Hospital, Oakland, CA, United States
  • b Northern California Sickle Cell Center, Oakland, CA, United States, Bruce Lyon Memorial Research Laboratory, Oakland, CA, United States, Department of Hematology/Oncology, Children's Hospital Medical Center of Northern California, Oakland, CA, United States, Department of Outpatient Services, Children's Hospital Medical Center of Northern California, Oakland, CA, United States, Hematology Division, San Francisco General Hospital, Oakland, CA, United States
  • c Northern California Sickle Cell Center, Oakland, CA, United States, Bruce Lyon Memorial Research Laboratory, Oakland, CA, United States, Department of Hematology/Oncology, Children's Hospital Medical Center of Northern California, Oakland, CA, United States, Department of Outpatient Services, Children's Hospital Medical Center of Northern California, Oakland, CA, United States, Hematology Division, San Francisco General Hospital, Oakland, CA, United States
  • d Northern California Sickle Cell Center, Oakland, CA, United States, Bruce Lyon Memorial Research Laboratory, Oakland, CA, United States, Department of Hematology/Oncology, Children's Hospital Medical Center of Northern California, Oakland, CA, United States, Department of Outpatient Services, Children's Hospital Medical Center of Northern California, Oakland, CA, United States, Hematology Division, San Francisco General Hospital, Oakland, CA, United States
  • e Northern California Sickle Cell Center, Oakland, CA, United States, Bruce Lyon Memorial Research Laboratory, Oakland, CA, United States, Department of Hematology/Oncology, Children's Hospital Medical Center of Northern California, Oakland, CA, United States, Department of Outpatient Services, Children's Hospital Medical Center of Northern California, Oakland, CA, United States, Hematology Division, San Francisco General Hospital, Oakland, CA, United States

Abstract

Hematologic evaluations of 254 Southeast Asian refugee children from 163 families are reported.Hemoglobin E trait was common in Cambodians (19%) and Laotians (18%), but rare in Vietnamese (1%). β-Thalassemia trait was most prevalent in Vietnamese (8%), and less common in Cambodians and Laotians (3%). α-Thalassemia was prevalent in all three groups. Hemoglobin concentrations and mean corpuscular volumes seen with hemoglobinopathies were compared with those of Southeast Asian children with normal hemoglobin. Both Hb AE and Hb EE were shown to be benign conditions resulting in microcytosis and mild, if any, anemia. In children with Hb AE, mean corpuscular volume ranged from 64 to 78 fl and Hb E from 27% to 34%. In those with Hb EE, microcytosis was more marked (50 to 63 fl). In 15 children with Hb EE, there was a delayed fall in fetal hemoglobin, which can cause diagnostic difficulties in infants. © 1983 The C. V. Mosby Company.

Author Keywords

[No Keywords available]

Index Keywords

Vietnam thalassemia Hemoglobins, Abnormal refugee Cambodia Laos human Refugees Asia hemoglobin f hemoglobin e mean corpuscular volume geographic distribution Humans anemia Adolescent Hemoglobinopathies Child, Preschool clinical article diagnosis beta thalassemia Age Factors ethnic or racial aspects alpha thalassemia congenital disorder microcytosis blood and hemopoietic system Child
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0020608261&doi=10.1016%2fS0022-3476%2883%2980235-2&partnerID=40&md5=b10410cfc519560b8d743cae35e92938
DOI: 10.1016/S0022-3476(83)80235-2
ISSN: 00223476
Cited by: 20
Original Language: English