Neurology
Volume 32, Issue 11, 1982, Pages 1221-1226

Parkinsonism-dementia in a filipino migrant: A clinicopathologic case report (Article)

Chen K.-M.* , Makifuchi T. , Garruto R.M. , Gajdusek D.C.
  • a NINCDS Research Center, Tamuning, Guam
  • b NINCDS Research Center, Tamuning, Guam
  • c Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States
  • d Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States

Abstract

A 69-year-old male Filipino migrant developed a clinical syndrome and neuropathologic changes indistinguishable from parkinsonism-dementia (PD). The patient originally migrated from the Ilocos region of the Philippine Islands to Hawaii and then to Guam, where he remained for 26 years before neurologic symptoms began. This is the first case of clinically and neuropathologically verified PD in a non-Chamorro and supports the notion that long-term continuous exposure to the Guamanian environment increases the risk of developing disease. © 1982 American Academy of Neurology.

Author Keywords

[No Keywords available]

Index Keywords

male case report central nervous system Parkinson disease Aged Transients and Migrants nervous system Dementia Philippines parkinsonism Substantia Nigra Guam histology human autopsy

Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0020423707&partnerID=40&md5=7fa80f7ec8927786c0f352ef462de2c5

ISSN: 00283878
Cited by: 17
Original Language: English