AIDS Research and Human Retroviruses
Volume 33, Issue 3, 2017, Pages 275-278

Near Full-Length Genomic Characterization of a Novel HIV-1 Unique Recombinant (CRF55-01B/CRF07-BC) from a Malaysian Immigrant Worker in Zhejiang, China (Article)

Wang H. , Luo P. , Zhu H. , Wang N. , Hu J. , Mo Q. , Yang Z. , Feng Y.*
  • a Zhuhai International Travel Healthcare Center, Zhuhai, China
  • b Zhejiang International Travel Healthcare Center, Hangzhou, China
  • c Beijing International Travel Healthcare Center, Beijing, China
  • d Yunnan International Travel Healthcare Center, Kunming, China
  • e State Key Laboratory for Infectious Disease Prevention and Control, Division of Virology and Immunology, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155 Changbai Road, Changping District, Beijing, 102206, China
  • f Zhuhai International Travel Healthcare Center, Zhuhai, China
  • g Zhuhai International Travel Healthcare Center, Zhuhai, China
  • h State Key Laboratory for Infectious Disease Prevention and Control, Division of Virology and Immunology, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155 Changbai Road, Changping District, Beijing, 102206, China

Abstract

Recombinant forms contribute substantially to the genetic diversity of human immunodeficiency virus type 1 (HIV-1). Here we report a novel HIV-1 recombinant detected from a comprehensive HIV-1 molecular epidemiologic study among cross-border populations in China. Near full-length genome (NFLG) phylogenetic analysis showed that the novel HIV-1 recombinant ZJCIQ15005, which was isolated from a Malaysian immigrant worker in Zhejiang, China, clustered with CRF55-01B reference sequences but set up a distinct branch. Recombinant analysis showed that the NFLG of ZJCIQ15005 composed of CRF55-01B (as the backbone) and CRF07-BC, with 12 recombinant break points observed in the pol, vif, vpr, tat, rev, env, nef, and 3′LTR regions. This is the first detection of a novel HIV-1 recombinant (CRF55-01B/CRF07-BC) in immigrant workers in China. The emergence of this recombinant may increase the complexity of the HIV-1 epidemic in China and suggests the importance of continuous surveillance of the dynamic changes of HIV-1. © 2017, Mary Ann Liebert, Inc. 2017.

Author Keywords

China URF HIV recombinant

Index Keywords

genetics China immigrant DNA sequence envelope protein HIV Infections Recombination, Genetic Rev protein molecular evolution Sequence Analysis, DNA Human immunodeficiency virus infection Evolution, Molecular transactivator protein gene mapping Genome, Viral genetic recombination Nef protein Vpr protein Vif protein virus strain human virus recombinant Malaysian priority journal virus isolation nucleotide sequence Pol protein cluster analysis Humans migrant Genomics classification virology virus detection male Emigrants and Immigrants case report virus genome isolation and purification Article epidemic Phylogeny adult HIV-1 gene sequence Human immunodeficiency virus 1
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014437194&doi=10.1089%2faid.2016.0100&partnerID=40&md5=0dd5e15de06e1d9905397cbda54ef8bc
DOI: 10.1089/aid.2016.0100
ISSN: 08892229
Cited by: 2
Original Language: English