International Journal of Cancer
2019

The disparities in gastrointestinal cancer incidence among Chinese populations in Shanghai compared to Chinese immigrants and indigenous non-Hispanic white populations in Los Angeles, USA (Article)

Liu Z. , Lin C. , Mu L. , Suo C. , Ye W. , Jin L. , Franceschi S. , Zhang T.* , Chen X.
  • a State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China, Fudan University Taizhou Institute of Health Sciences, Taizhou, China
  • b International Agency for Research on Cancer, Lyon, France
  • c Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, State University of New York (SUNY) at Buffalo, Buffalo, NY, United States
  • d Fudan University Taizhou Institute of Health Sciences, Taizhou, China, Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China, Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, China
  • e Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  • f State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China, Fudan University Taizhou Institute of Health Sciences, Taizhou, China, Human Phenome Institute, Fudan University, Shanghai, China
  • g Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy
  • h Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China, Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, China
  • i State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China, Fudan University Taizhou Institute of Health Sciences, Taizhou, China, Human Phenome Institute, Fudan University, Shanghai, China

Abstract

Gastrointestinal cancer patterns are distinct among populations. Our study aims to compare the incidence and risk of gastrointestinal cancers between Chinese American and non-Hispanic whites in Los Angeles, CA, USA, to those of people indigenous to Shanghai to elucidate the changing patterns of gastrointestinal cancers. Cancer incidence data from 1988 to 2012 were extracted from the Cancer Incidence in Five Continents plus database. The age standardized incidence and estimated annual percentage change were calculated to estimate the temporal trends of gastrointestinal cancers. Traditional Poisson regression models and three-factor constrained Poisson regression models were applied to compare the gastrointestinal cancer risk across populations. The incidences of oesophageal, stomach, liver and gall bladder cancers were higher among indigenous Chinese residents of Shanghai than among the other two populations in Los Angeles. While the incidences of colorectal and pancreatic cancer were higher among non-Hispanic whites, Chinese American immigrants were considered to be at an intermediate level for most gastrointestinal cancers. The gender-specific gastrointestinal cancer disparities across populations, especially between Shanghai Chinese and non-Hispanic US whites, were significant regardless of age, period or cohort scale. However, the regional differences in gastrointestinal cancer rates decreased over time. Most gastrointestinal cancer patterns in Chinese American immigrants were more aligned to those of their new country of residence than to those of their original country. The disparities in gastrointestinal cancers across populations indicate that environmental factors might play a key role in cancer genesis. Shift in environmental exposures may result in significant changes in gastrointestinal cancer incidence. © 2019 UICC

Author Keywords

Incidence gastrointestinal cancer Chinese immigrants

Index Keywords

[No Keywords available]
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063238197&doi=10.1002%2fijc.32251&partnerID=40&md5=b0ea7704c127d05ab132ab5726765cd8
DOI: 10.1002/ijc.32251
ISSN: 00207136
Original Language: English