Fetal Diagnosis and Therapy
Volume 26, Issue 4, 2009, Pages 200-202

Maternal serum triple marker levels in immigrants to Israel from ethiopia (Article)

Sharony R.* , Itzhaky D. , Amiel A. , Fejgin M. , Cuckle H.
  • a Genetic Institute, Sapir Medical Center, Meir Hospital, IL-44281 Kfar Saba, Israel, Department of Obstetrics and Gynecology, Kfar Saba
  • b Immunology Laboratory, Sapir Medical Center, Meir Hospital, Kfar Saba, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
  • c Faculty of Life Science, Bar Illan University, Ramat Gan, Israel
  • d Genetic Institute, Sapir Medical Center, Meir Hospital, IL-44281 Kfar Saba, Israel, Department of Obstetrics and Gynecology, Kfar Saba
  • e Department of Obstetrics and Gynecology, Columbia University, New York, NY, United States

Abstract

Objectives: To determine if Ethiopian immigrants have similar triple marker levels as the general Israeli population. Material and Methods: Second-trimester maternal serum results on 346 Ethiopians were obtained from records of 36,309 women. Two series were constructed for comparison among patients screened between 2000 and 2001 ('old group') and 2005 and 2007 ('new group'). Results: The median and 95% confidence intervals (CI) were: α-fetoprotein (AFP) 1.080 multiples of median (MoM) (95% CI 1.03-1.13); human chorionic gonadotrophin (hCG) 0.895 MoM (95% CI 0.82-0.97), and unconjugated estriol (uE3) 1.050 MoM (95% CI 1.00-1.10). The differences between the AFP and hCG medians for the old and new series were not statistically significant (p = 0.06 and 0.20) whilst the uE3 difference was significant (p = 0.04). There was a general tendency for the levels to be closer to 1 MoM over time. Conclusions: Triple marker serum levels of AFP and hCG among Ethiopian patients may need to be slightly corrected, particularly for hCG. Copyright © 2009 S. Karger AG, Basel.

Author Keywords

Triple test Ethiopians Genetic tendency

Index Keywords

information processing immigrant Israel human controlled study priority journal Estriol alpha-Fetoproteins Chorionic Gonadotropin alpha fetoprotein maternal serum screening Pregnancy Trimester, Second Confidence interval blood level Humans Emigrants and Immigrants female pregnancy marker Article Ethiopia major clinical study Biological Markers second trimester pregnancy
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-73749087852&doi=10.1159%2f000261896&partnerID=40&md5=177e3a5f1967bde66894f71953b2c03e
DOI: 10.1159/000261896
ISSN: 10153837
Cited by: 1
Original Language: English