Journal of Infection
Volume 59, Issue 4, 2009, Pages 259-263

The case for outpatient treatment of Plasmodium falciparum malaria in a selected UK immigrant population (Article)

Melzer M.* , Lacey S. , Rait G.
  • a King George and Queen's Hospitals, Barking, Havering and Redbridge Trust, Barley Lane, Goodmayes, Essex IG3 8YB, United Kingdom
  • b King George and Queen's Hospitals, Barking, Havering and Redbridge Trust, Barley Lane, Goodmayes, Essex IG3 8YB, United Kingdom
  • c Medical Research Council General Practice Research Framework, 158-160 North Gower St., London NW1 2ND, United Kingdom

Abstract

UK guidance recommends that all patients with falciparum malaria be admitted to hospital, although a number of cohort studies in the developed world demonstrate that outpatient treatment of falciparum malaria is feasible and safe in selected patients. We review the literature on outpatient treatment in developed countries and present local data from East London where a selected immigrant population were successfully treated as outpatients. Although it is premature to claim that outpatient treatment of falciparum malaria is safe in all selected patients, we conclude it is time for a large UK-based safety study or randomised trial to dispel the belief that all patients with uncomplicated Plasmodium falciparum must be admitted to hospital. © 2009.

Author Keywords

Out of hospital Plasmodium falciparum Outpatient Treatment

Index Keywords

halofantrine atovaquone plus proguanil immigrant hospitalization London human health belief outpatient care doxycycline Humans treatment duration Treatment Outcome Antimalarials combination chemotherapy Article Parasitemia artemisinin Malaria, Falciparum United Kingdom malaria falciparum Plasmodium falciparum ambulatory care artemether plus benflumetol fansidar quinine mefloquine
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-72149115184&doi=10.1016%2fj.jinf.2009.08.010&partnerID=40&md5=5666b511482204b091f57f2f3eb5f29e
DOI: 10.1016/j.jinf.2009.08.010
ISSN: 01634453
Cited by: 9
Original Language: English