New Microbiologica
Volume 32, Issue 4, 2009, Pages 369-376

A QuantiFERON®-TB Gold In-Tube test (QFT-GIT) for the screening of latent tuberculosis in recent immigrants to Italy (Article)

Saracino A.* , Scotto C. , Fornabaio C. , Martinelli D. , Faleo G. , Cibelli D. , Tartaglia A. , Di Tullio R. , Fazio V. , Prato R. , Monno L. , Angararto G.
  • a Clinic of Infectious Diseases, University of Foggia, V.le L. Pinto, 1, 71100 Foggia, Italy
  • b Clinic of Infectious Diseases, University of Foggia, V.le L. Pinto, 1, 71100 Foggia, Italy
  • c Clinic of Infectious Diseases, University of Foggia, V.le L. Pinto, 1, 71100 Foggia, Italy
  • d Department of Medical and Occupational Science, Section of Hygiene, University Offoggia, Italy
  • e Clinic of Infectious Diseases, University of Foggia, V.le L. Pinto, 1, 71100 Foggia, Italy
  • f Clinic of Infectious Diseases, University of Foggia, V.le L. Pinto, 1, 71100 Foggia, Italy
  • g Clinic of Infectious Diseases, University of Foggia, V.le L. Pinto, 1, 71100 Foggia, Italy
  • h Clinic of Infectious Diseases, University of Foggia, V.le L. Pinto, 1, 71100 Foggia, Italy
  • i Clinical Chemistry Laboratory, Ospedali Riuniti of Foggia, Italy
  • j Department of Medical and Occupational Science, Section of Hygiene, University Offoggia, Italy
  • k Clinic of Infectious Diseases, University of Bari, Italy
  • l Clinic of Infectious Diseases, University of Foggia, V.le L. Pinto, 1, 71100 Foggia, Italy

Abstract

To evaluate the agreement between QuantiFERON®-TB Gold In-Tube test (QFT-GIT) and tuberculin skin test (TST) for the screening of latent tuberculosis infection (LTBI) in recent immigrants to Italy, 279 subjects were submitted to concomitant TST and QFT-GIT. The agreement was analyzed using k statistics. A total of 72/279 (25.8%) individuals were TST positive, while 107/279 (38.3%) were QFT-GIT positive. The overall agreement between QFT-GIT and TST was 70.9%, with k statistic of 0.35. Using different TST and QFT-GIT cut-offs, the best concordance value was obtained for QFT-GIT at >2.64 IU/ml and TST at >10mm (κ=0.409). Discordant results were found for 58 subjects (21%) with QFT-GIT positive/TST negative and 23 (8%) with QFT-GIT negative/TST positive. A high amount of discordance QFTGIT+/TST- was described. QFT-GIT might increase the identification of LTBI cases among recent immigrants.

Author Keywords

QuantiFERON®-TB Gold In-Tube immigrants Latent tuberculosis TB screening

Index Keywords

evaluation mass screening methodology human Skin Tests Mycobacterium tuberculosis Young Adult Humans lung tuberculosis skin test male analytical equipment Tuberculosis, Pulmonary latent tuberculosis Emigrants and Immigrants female gamma interferon immunology Article blood adult migration Italy Interferon-gamma Reagent Kits, Diagnostic
Link
https://www.scopus.com/inward/record.uri?eid=2-s2.0-74349114118&partnerID=40&md5=de5565ad4bc0d62913fcc660ed7f8eb1
ISSN: 11217138
Cited by: 18
Original Language: English